Jamal Bryant
Department: Pharmacology
Faculty Mentor: Ethan Lee, M.D., Ph.D.
Dissertation Description: Novel kinase regulation of Wnt pathway activation
The canonical Wnt/β-catenin signaling pathway is a key regulator of human development and tissue homeostasis, and aberrant Wnt activation contributes to numerous disorders (e.g. cancer and cardiovascular disease). Kinase activity within multi-protein complexes is critical in regulating the Wnt pathway. My research uses biochemistry, cell biology, and molecular pharmacology to investigate the role of novel kinases in regulating Wnt receptor activation.