Obesity Dyslipidemia: The Effect of Central Nervous System Neuropeptide Y on Hepatic Lipoprotein Metabolism
My research is focused on obesity related dyslipidemias, at the level of central nervous system (CNS) control of lipoprotein metabolism. The aim of these studies is to investigate mechanisms by which CNS neuropeptide Y (NPY) signaling leads to rapid and dramatic increases in hepatic very low-density lipoprotein-triglyceride secretion in lean fasted rats. I have identified CNS NPY receptor subtypes involved and have uncovered several novel liver lipo-regulatory mechanisms that are modulated by CNS NPY inputs. This work has overarching implications in further understanding how obesity related CNS dysfunction (characterized by elevated CNS NPY tone) contributes to the pathophysiology of metabolic syndrome.