Cannabinoid Receptor 1 Signaling in the Amygdala
My thesis research project focuses on the role of the endocannabinoid system in stress-induced maladaptations in the mouse brain, specifically the amygdala. By investigating stress-induced changes in the amygdala, mechanisms that underlie stress-related neuronal plasticity and remodeling leading to fear and anxiety can be determined. In this research project, I will investigate the molecular mechanisms involving the endocannabinoid system, specifically signaling through cannabinoid receptor 1 (CB1R), which underlie the development and exacerbation of anxiety-like behaviors in rodents. These investigations will involve the use of electrophysiological recordings in brain slices and a variety of behavioral and biochemical techniques.