The Role of Cardiac Ankyrin Repeat Protein in Wound Healing
The overall goal of my project is to study the role cardiac ankyrin repeat protein (Ankrd1/CARP) plays in tissue repair. Data from Ankrd1/CARP overexpression and deletion showed Ankrd1/CARP involvement in neovascularization, a critical aspect of the wound healing process. Studies in our lab have shown that Ankrd1/CARP is capable of stimulating neovascularization in a number of wound-healing models. We hypothesize that Ankrd1/CARP utilizes novel signaling pathways for its proangiogenic effects. One of my research objectives is to determine how Ankrd1/CARP affects tissue repair through provisionally identified targets such as integrins and matrix metalloproteinases. Results derived from this study can lead to the delineation of new mechanisms that regulate wound angiogenesis.