Krystal Tsosie

Krystal Tsosie

Human Genetics

PI: Todd Edwards, Ph.D.

Genetic Determinants of Complex Diseases and Racial Health Disparities

Vanderbilt University has the largest collection of electronic medical records linked with patient genetic information in a database called BioVU. This impressive resource enables me to investigate the complex determinants of diseases - in particular uterine fibroids and keloids - that have a disproportionally large burden in African Americans.  Most of my analyses look at distributions of genetic loci across populations, as determined through techniques like genome-wide association studies (GWAS) and exome genotyping, to look for heritable factors that modiulate disease risk.  I also employ large-scale epidemiology study design and computational biostatistics approaches to model clinical factors that lead to stratification of health outcomes in the context of racial health disparities.