Lorena Infante Lara

Lorena Infante Lara

Biochemistry

PI: Neil Osheroff, Ph.D.

The relationship between human topoisomerase II alpha and DNA damage repair pathways

Our lab looks at human and bacterial topoisomerases, essential nuclear enzymes that help detangle and change the supercoiling state of DNA by cleaving one molecule of DNA and passing another one through, or by cleaving one strand and twisting the other before religating it. The cleavage function of topoisomerases can be enhanced with drugs called topoisomerase poisons, making them important antibiotic or chemotherapeutic targets. My research will primarily be focused on characterizing the relationship between human topoisomerase II alpha and DNA damage repair pathways, given that abasic sites - intermediate states during repair pathways like BER - have been found to act as topoisomerase poisons.