Mechanisms Controlling Photoreceptor Differentiation in Zebrafish
The Patton Lab is investigating multiple facets of retinal regeneration. My project in this area involves photoreceptor differentiation, and the possibility to control whether photoreceptor precursor cells differentiate into either rod cells or cone cells. In our studies, we use zebrafish as a model organism due to their ability to regenerate most tissues in their body, including the retina. I am currently developing a cone ablation model, which will selectively kill cone cells. This, in combination with a previously developed rod ablation model, will allow for further studies in controlling photoreceptor differentiation.