Molecular Mechanisms Facilitating Metastasis of Oral Squamous Carcinoma
In the Sterling lab we study the mechanisms that enable certain cancer types to metastasize to bone. These include breast, lung, oral, renal, and prostate cancer. My projects mainly involve oral squamous cellular carcinoma and molecular mechanisms facilitating its metastasis to the lower jaw. We are especially interested in understanding the role of bone rigidity and PTHrP (Para Thyroid Hormone related Protein) in cancer progression in the bone microenvironment. Our lab utilizes basic bench research techniques, such as RT-PCR as well as pre-clinical systems using mouse models and sophisticated imaging equipment to conduct our research.