Role of BVES, a Tight Junction Protein, in Cancer
I am interested in junctional biology and cancer. Tight junctions between epithelial cells regulate the passage of molecules through the epithelial barrier. Dysregulation of junctional complexes plays a role in cancer development. Recent studies from our lab have shown that BVES, a tight junction protein, is down regulated in colon cancer and restoring expression of BVES in cancer cell lines promotes epithelial-like features. The main goal of my project is to understand how BVES and BVES-interacting proteins are regulated in cancer. I am using complimentary mouse and cell culture models to understand BVES mediated signaling events in cancer.