The Role of Lipid Oxidation after Radiation-induced Pulmonary Injury
Normal tissue toxicity is a limiting factor in radiation therapy in advanced stage lung cancer. Subsets of patients who have undergone radiation therapy develop radiation-induced pulmonary injury. It is well-established that ionizing radiation induces oxidative stress that generates lipid oxidation products. Lipid oxidation products have been shown to react with protein, lipid membranes and DNA. What is not well understood, are the specific types of lipid products formed after ionizing radiation, their targets, and their role in radiation-induced pulmonary injury. This research seeks to understand the role of lipid oxidation products which occur after ionizing radiation in the context of pulmonary-injury. The goal of this project is to identify novel targets to help decrease normal tissue damage after lung cancer radiation therapy.