Jeffrey Rathmell, PhD
Dr. Rathmell studies mechanisms by which extracellular cues influence lymphocyte death and differentiation in efforts to control inflammatory diseases and leukemia. Following undergraduate studies on Biology at the University of Northern Iowa, his earned a PhD in Immunology on B cell tolerance and death mechanisms at Stanford University. In postdoctoral studies at the University of Chicago and University of Pennsylvania, he showed that lymphocyte metabolism was dynamically regulated by growth factors and controls apoptotic mechanisms. He began at Duke University in 2003 in the departments of Pharmacology and Cancer Biology and Immunology, as well as a member of the Duke Molecular Physiology Institute. At Duke, Dr. Rathmell showed that glucose uptake and metabolism in T cells are highly dynamic and critical in the metabolic reprogramming and survival of both effector T cells and leukemic cells. Dr. Rathmell also showed that suppressive regulatory T cells do not undergo this transition and instead continue to rely on oxidative metabolism. This fundamental metabolic distinction may now allow selective immune modulation. Dr. Rathmell continues to examine the regulation of metabolic programs of lymphocytes in inflammatory disease, anti-tumor immunity, and in leukemia. In addition to laboratory work, Dr. Rathmell is an editor of the Journal of Clinical Investigation, and was the Director of Graduate Studies in Pharmacology at Duke University. In 2015 he joined the faculty of Vanderbilt University as Professor of Pathology, Microbiology, and Immunology to direct the new Vanderbilt Center for Immunobiology and co-lead the Vanderbilt Ingram Cancer Center Host Tumor Interactions Program.
Current Post-Doctoral Fellows
Peter Siska, M.D.
Sivan Cohen, Ph.D.
Gabriela Andrejeva, Ph.D.
Katy Beckermann, M.D./Ph.D.
Current Graduate Students
Rigel Kishton Molecular Cancer Biology (Duke)
Marc Johnson Pharmacology (Duke)
Diana Contreras Microbiology and Immunology (Vanderbilt)
Past Post-Doctoral Fellows
Nancie MacIver, M.D./Ph.D.
Assistant Professor (tenure track) Duke University, Pediatric Endocrinology
Liza Makowski, Ph.D.
Assistant Professor (tenure track) University of North Carolina at Chapel Hill, Nutrition
Ryan Michalek, Ph.D.
Senior Study Director, Metabolon Inc., Durham, NC
Pankuri Goraska-Hicks, Ph.D.
Director of Oncology Studies, Gentris
Alfredo Caro-Maldonado, Ph.D.
Post-doctoral Researcher, CIC BioGUNE, Spain
Andrew Macintyre, Ph.D.
Education and Professional Development Manager at American Society for Biochemistry and Molecular Biology (ASBMB)
Past Graduate Students from the Rathmell Lab
Pharm Defended PhD 11/29/2007
Current Clinical Scientist-Drug Development, Aratana Therapeutics, Kansas City, MO
Pharm Defended PhD 12/6/2007
Currently a Police Officer, Melbourne Australia.
MCB Defended PhD 04/08
Senior Scientist, ZenBio, Research Triangle Park, NC
IMM Defended M.S. 2009
Associate Veterinarian at United Veterinary Specialty and Emergency, San Francisco
MCB Defended PhD 11/09
Current Post-doc with Blossom Damania at UNC Chapel Hill
Emily F Mason
MCB/MSTP Defended PhD 7/10
Currently a Pathology fellow at Brigham and Women’s Hospital
Pharm Defended PhD 9/10
Post-doc with Joan Brugge at Harvard Univeristy
Brian J. Altman
MCB Defended PhD 5/11
Post-doc with Chi Dang, University of Pennsylvania
Valerie A. Gerriets
Pharm Defended PhD 2/21/14
Post-doc with Nancie MacIver, Duke University
Pharm Defended PhD 10/20/14
Post-doc with Jeffrey Engelman, Harvard University