Our lab group is interested in the basic mechanism of Wnt signal transduction, a pathway that plays critical roles in the early development of multicellular organisms and the maintenance of stem cells in adults. The Wnt pathway is also inappropriately activated in many human cancers. We use tools of biochemistry, chemical biology, cell biology, and developmental biology to study the Wnt pathway. Major questions we are addressing include the following:
1) How is receptor homeostasis maintained?
2) What are the nuclear factors needed to mediate Wnt signaling?
3) How do mutations in tumor suppressors and oncogenes lead to pathway perturbation?
A long-term goal of our lab group is to leverage the findings from these and other studies to develop effective therapeutics for the treatment of Wnt-driven diseases.