Imam Uddin, Ph.D.

Imam Uddin, Ph.D.

Research Instructor of Ophthalmology and Visual Sciences, Vanderbilt University School of Medicine, Marnett Lab

Dr. Uddin is a young investigator and his research is focused on the development of molecular imaging technologies including optical imaging, optical coherence tomography (OCT) and nano-scale engineering to identify molecular targets for early disease-detection and treatments in ophthalmology, vascular medicine and oncology. Dr. Uddin is currently using optical imaging techniques and nanotechnology-based approaches for diagnosis and drug delivery in preclinical models of diabetic retinopathy (DR), retinopathy of prematurity (ROP), retinal vein occlusion (RVO) and age-related macular degeneration (AMD).

 

AFFILIATIONS

Member: The American Chemical Society

Member: The Society of Nuclear Medicine and Molecular Imaging

Member: The Association for Research in Vision and Ophthalmology (ARVO).
 

ACADEMIC PRESENTATIONS

1. VCAM-1 targeted in vivo imaging of neovascular disease in a preclinical model. Uddin, M. I.; Evans, SM.; Wong, A.; Wright, D.; Jayagopal, A.; Penn JS. ARVO 2016, Seattle, Washington (May1-5)

 

PATENTS APPLICATIONS

1. Compositions and Method for Detecting Hypoxia. Uddin, M. I.; Jayagopal. A.; Uddin, MJ.; Penn, JS.; Marnett, LJ. U.S. Provisional Application Serial No. 62/156,055, filed May 1, 2015, and U.S. Provisional Application Serial No. 62/294,210, filed February 11, 2016.

2. PCT conversion of 62/294,210 and 62/156,055. Compositions and Method for Detecting Hypoxia. Uddin, M. I.; Jayagopal. A.; Uddin, MJ.; Penn, JS.; Marnett, LJ. filed May, 2016.

 

BOOK CHAPTER

1. The Synthesis and Properties of Dipyrrins. Wood, T.E.; Uddin, M. I.; Thompson, A. “The Porphyrin Handbook” with applications to chemistry, physics, materials science, engineering, biology and medicine, Kadish, K.M.; Smith, K.; Guilard, R. (Eds.), 2010, 8, 235-291.

 

PUBLICATIONS

28. Characterization and In Vivo Detection of Retinal Hypoxia in a Mouse Model of Laser-induced Retinal Vein Occlusion (RVO). Uddin, M. I.; Evans, S. M.; McCollum, G. W.; Yang, R.; Gordon, A.; Jayagopal, A.; Penn, J. S. Submitted, 2016.  

27. In Vivo Imaging of Retinal Hypoxia in a Model of Oxygen-Induced Retinopathy. Uddin, M. I.; Evans, S. M.; Craft, J. R.; Capozzi, M. E.; McCollum, G. W.; Yang, R.; Marnett, L. J.; Uddin, M. J.; Jayagopal, A.; Penn, J. S. Scientific Reports, 2016, 6, 31011. 

26. Applications of azo-based probes for imaging retinal hypoxia. Uddin, M. I., Evans, S. M., Craft, J. R., Marnett, L. J., Uddin, M. J. Joyagopal, A. ACS Medicinal Chemistry Letters, 2015, 6 (4), 445-449.

25. Nanoengineering of therapeutics for retinal vascular disease. Gahlaut, N.; Suarez, S.; Uddin, M. I.; Gordon, A. Y.; Evans, S. M.; Jayagopal, A. Eur. J. Pharm. Biopharm. 2015, 95, 323-330.

23. Molecular Probes for Imaging of Hypoxia in the Retina. Evans, S. M.; Kim, K.; Moore, C. E.; Uddin, M. I.; Capozzi, M. E.; Craft, J. R.; Sulikowski, G. A.; J. Joyagopal, A. Bioconjugate Chem., 2014, 25 (11), 2030–2037.

22. Microwave-Assisted, One-Pot Reactions of 7-Azaindoles and Aldehydes: A Facile Route to Novel Di-7-azaindolylmethanes. Uddin, M. I.; Buck, J. R.; Schulte, M. L.; Tang, D.; Saleh, S. A.; Yiu-Yin Cheung, Yiu-Yin.; Harp, J.; Manning, H. C. Tetrahedron Letters, 2014, 55, 169-173.

21. Synthesis and Antimalarial Activity of Prodigiosenes. Marchal; E.; Smithen, D. A.; Uddin Md. I. Robertson, A. W.; Jakeman, D. J.; Mollard,.; MacDougall, K. S.; McFarland, S. A.; McFadden, G. I.; Thompson, A. Org. Biomol. Chem. 2014, Accepted.

20. Microwave-Assisted, One-Pot Reactions of 7-Azaindoles and Aldehydes: A Facile Route to Novel Di-7-azaindolylmethanes. Uddin, Md. I.; Buck, J. R.; Schulte, M. L.; Tang, D.; Saleh, S. A.; Yiu-Yin Cheung, Yiu-Yin.; Harp, J.; Manning, H. C. Tetrahedron Letters, 2014, 55, 169-173.

19. Antimicrobial activity of non-natural prodigiosenes. Marchal, E.; Uddin, M. I.; Smithen, D. A.; Hawco, C. L. C.; Lanteigne, M.; Overy, D. P.; Keer, R. G.; Thompson, A. RSC Adv., 2013, 3, 22967-22971.

18. Synthesis and biological evaluation of prodigiosene conjugates of porphyrin, estrone and 4-hydroxytamoxifen. Hawco, C.L.A., Marchal, E.; Uddin, M. I., Alexander E.G. Baker, Dale P. Corkery, Graham Dellaire, Alison Thompson. Bioorg. Med. Chem., 2013, 21, 5995-6002.

17. Synthetic prodigiosenes and the influence of C-ring substitution on DNA cleavage, transmembrane chloride transport and basicity. Rastogi, S.; Marchal, E.; Uddin, M. I.; Groves, B.; Colpitts, J.; McFarland, S.A.; Jeffery T. Davis, J.T.; Thompson, A. Org. Biomol. Chem., 2013,11, 3834-3845.

16. Synthesis and Structure–Activity Relationships of 5,6,7-Substituted Pyrazolopyrimidines: Discovery of a Novel TSPO PET Ligand for Cancer Imaging. Dewei Tang, Eliot T. McKinley, Matthew R. Hight, Uddin, M. I., Joel M. Harp, Allie Fu, Michael L. Nickels, Jason R. Buck, and H. Charles Manning. J. Med. Chem. 2013, 56, 3429−3433. Plus cover art chosen by The American Chemical Society.

15. 3′-Deoxy-3′-18F-Fluorothymidine PET Predicts Response to V600EBRAF-Targeted Therapy in Preclinical Models of Colorectal Cancer. Eliot T. McKinley, R. Adam Smith, Ping Zhao, Allie Fu, Samir A. Saleh, Uddin, M. I., M. Kay Washington, Robert J. Coffey, and H. Charles Manning. J. Nucl. Med. 2013, 54, 424-430.

14. Antimicrobial activity of non-natural prodigiosenes. Marchal, E.; Uddin, Md. I.; Smithen, D. A.; Hawco, C. L. C.; Lanteigne, M.; Overy, D. P.; Keer, R. G.; Thompson, A. RSC Adv., 2013, 3, 22967-22971.

13. Synthesis and biological evaluation of prodigiosene conjugates of porphyrin, estrone and 4-hydroxytamoxifen. Hawco, C.L.A., Marchal, E.; Uddin, Md. I., Alexander E.G. Baker, Dale P. Corkery, Graham Dellaire, Alison Thompson. Bioorg. Med. Chem., 2013, 21, 5995-6002.

12. Synthetic prodigiosenes and the influence of C-ring substitution on DNA cleavage, transmembrane chloride transport and basicity. Rastogi, S.; Marchal, E.; Uddin, Md. I.; Groves, B.; Colpitts, J.; McFarland, S.A.; Jeffery T. Davis, J.T.; Thompson, A. Org. Biomol. Chem., 2013,11, 3834-3845.

11. Synthesis and Structure–Activity Relationships of 5,6,7-Substituted Pyrazolopyrimidines: Discovery of a Novel TSPO PET Ligand for Cancer Imaging. Dewei Tang, Eliot T. McKinley, Matthew R. Hight, Uddin, Md. I., Joel M. Harp, Allie Fu, Michael L. Nickels, Jason R. Buck, and H. Charles Manning. J. Med. Chem. 2013, 56, 3429−3433. Plus cover art chosen by The American Chemical Society.

10. 3′-Deoxy-3′-18F-Fluorothymidine PET Predicts Response to V600EBRAF-Targeted Therapy in Preclinical Models of Colorectal Cancer. Eliot T. McKinley, R. Adam Smith, Ping Zhao, Allie Fu, Samir A. Saleh, Uddin, Md. I., M. Kay Washington, Robert J. Coffey, and H. Charles Manning. J. Nucl. Med. 2013, 54, 424-430.

9.  Rapid, Microwave-Assisted Organic Synthesis of Selective V600EBRAF Inhibitors for Preclinical Cancer Research. Buck, J. R.; Saleh, S.; Uddin, M. I.; Manning, H. C. Tetrahedron Letters, 2012, 53, 4161-4165.

8. Synthesis of Heteroleptic Pyrrolide/Bipyridyl Complexes of Ruthenium(II). Lundrigan, T.; Jackson, C.L.M.; Uddin, Md. I.; Tucker, L.A. ; Al-Sheikh Ali, A.; Linden, A.; Cameron, T.S.; Thompson, A. Can. J. Chem. 2012, 90, 693-700.

7. Rapid, Microwave-Assisted Organic Synthesis of Selective V600EBRAF Inhibitors for Preclinical Cancer Research. Buck, J. R.; Saleh, S.; Uddin, Md. I.; Manning, H. C. Tetrahedron Letters, 2012, 53, 4161-4165.

6. Improved synthetic route to C-ring ester-functionalized prodigiosenes. Uddin, M. I., Thirumalairajan, S; Crawford, S. M.; Cameron, T. S.; Thompson, A. Synlett, 2010, 17, 2561-2564.

5. The Synthesis and Properties of Dipyrrins. Wood, T.E.; Uddin, M. I.; Thompson, A. “The Porphyrin Handbook” with applications to chemistry, physics, materials science, engineering, biology and medicine, Kadish, K.M.; Smith, K.; Guilard, R. (Eds.), 2010, 8, 235-291.

4. Microwave-assisted and Ln(OTf)3-catalyzed Homo-conjugate Addition of N-Heteroaromatics to Activated Cyclopropane Derivatives. Uddin, M. I.; Mimoto, A.; Nakano, K.; Ichikawa, Y.; Kotsuki, H. Tetrahedron Letters, 2008, 49, 5867-5870.

3. A Novel Method for the High-Pressure-Promoted Uncatalyzed Aza-Michael Reaction of Nitrogen Heterocycles with Enones in Water. Uddin, M. I.; Nakano, K.; Ichikawa, Y.; Kotsuki, H. Synlett, 2008, 9, 1402-1406.

2. Synthesis and preliminary evaluation of brominated 5-methyl-2,4-dihydropyrazol-3-one and its derivatives as cytotoxic agents. Rahat Khan, Uddin M. I.; Alam, S. M.; Hossain, M. M.; Islam, R. I. Bangladesh J. Pharmacol, 2008, 3, 27-35.

1. A novel design of roof-shaped anthracene-fused chiral prolines as organocatalysts for asymmetric Mannich reactions. Sasaoka, A.; Uddin, M. I.; Shimomoto, A.; Ichikawa, Y.; Shiro, M.; Kotsuki, H. Tetrahedron: Asymmetry 2006, 17, 2963-2969.

 

SELECTED TALKS

SLC7A11 and SLC1A5 Targeted Molecular-Probes: 18F-4FP-GLU and 18F-4F-GLN as Imaging-Biomarkers for Colon-Cancer. Uddin, Md. I.; Cheung, Yiu-Y.; Hight, M. R.; Buck, J. R.; Saleh, S. A.; Nickels, M.; McKinley, E. T.; Wilson, G. H.; Tantawy, N.; Manning, H. C. Frontiers of Biomedical Imaging Science IV, July 2013, Nashville TN.

Synthesis of an Optically Pure Sulfinate and its Utility in the Asymmetric Synthesis of Chiral Pyrrole-containing Diarylsulfoxides. Uddin, M. I.; Pearce, B.; Thompson, A. 93rd Canadian Chemistry Conference and Exhibition, May 2010, Toronto, ON.

Towards the Synthesis and Diastereoselective Complexation of Chiral Dipyrrinto and Bis(Dipyrrinato) Ligands. Cosh, H.A.; Pearce, B.M.; Uddin, M. I.; Thompson, A. 4th Banff Symposium on Organic Chemistry, October 2009, Banff, AB.

Synthesis of Chiral Sulfoxides and their Utility in Asymmetric Synthesis, Uddin, M. I.; Pearce, B.; Thompson, A. IRM Annual General Meeting and Research Day, June 2009, Dalhousie University, Halifax, Canada.

Conjugate Addition Reactions of N-Heterocycles to a,b-Unsaturated Enones and Activated Cyclopropane Derivatives under Extreme Conditions, Uddin, M. I.; Mimoto, A.; Kotsuki, H. 24th Summer Symposium for Young Synthetic Chemists, Japan, September 11-12, 2008.

High-Pressure Organic Chemistry. Conjugate Addition of N-Heterocycles to a,b-Unsaturated Enones in Water, Uddin, M. I.; Kotsuki, H. 88th Spring Meeting, The Chemical Society of Japan, Tokyo, March 26-30, 2008.

A Novel Design of Roof-shaped Anthracene-fused Chiral Prolines as Organocatalysts for Asymmetric Mannich Reactions, Sasaoka, A.; Uddin, M. I.; Shimomoto, A.; Ichikawa, Y.; Shiro, M.; Kotsuki, H. 10th International Kyoto Conference on New Aspects of Organic Chemistry (IKCOC-10), Kyoto, November 13-17, 2006.

A Novel Design of Roof-shaped Chiral Aryl-prolines as Organocatal-ysts for Asymmetric Transformations” Sasaoka, A., Uddin, M. I.; Shimomoto, A.; Ichikawa, Y.; Shiro, M.; Kotsuki, H. 36th Congress of Heterocyclic Chemistry, Nagasaki, November 22-24, 2006.