Publications

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2013 Publications

"Substrate-selective COX-2 inhibition decreases anxiety via endocannabinoid activation." Hermanson DJ, Hartley ND, Gamble-George J, Brown N, Shonesy BC, Kingsley PJ, Colbran RJ, Reese J, Marnett LJ, Patel S. Nat Neurosci. 2013 Sep;16(9):1291-8. doi: 10.1038/nn.3480. Epub 2013 Aug 4. PMID: 23912944 [PubMed - in process]

"Human platelets generate phospholipid-esterified prostaglandins via cyclooxygenase-1 that are inhibited by low dose aspirin supplementation." Aldrovandi M, Hammond VJ, Podmore H, Hornshaw M, Clark SR, Marnett LJ, Slatter DA, Murphy RC, Collins PW, O'Donnell VB. J Lipid Res. 2013 Jul 24. [Epub ahead of print] PMID: 23883581

"Cytotoxicity of 1,4-diamino-2-butanone, a putrescine analogue, to RKO cells: mechanism and redox imbalance." Soares CO, Boiani M, Marnett LJ, Bechara EJ. Free Radic Res. 2013 Jul 8. [Epub ahead of print] PMID: 23758064 

The 2'-Trifluoromethyl Analogue of Indomethacin Is a Potent and Selective COX-2 Inhibitor." Blobaum AL, Uddin MJ, Felts AS, Crews BC, Rouzer CA, Marnett LJ. ACS Med Chem Lett. 2013 May 9;4(5):486-490. Epub 2013 Mar 25. PMID: 23687559

Effect of Zileuton and Celecoxib on Urinary LTE4 and PGE-M Levels in Smokers." Mohebati A, Milne GL, Zhou XK, Duffield-Lillico AJ, Boyle JO, Knutson A, Bosworth BP, Kingsley PJ, Marnett LJ, Brown PH, Akpa EG, Szabo E, Dannenberg AJ. Cancer Prev Res (Phila). 2013 Jul;6(7):646-55. doi: 10.1158/1940-6207.CAPR-13-0083. Epub 2013 May 16. PMID: 23682075

"Molecular Imaging of Cyclooxygenase-2 in Canine Transitional Cell Carcinomas In Vitro and In Vivo".
Cekanova M, Uddin MJ, Bartges JW, Callens A, Legendre AM, Rathore K, Wright L, Carter A, Marnett LJ. Cancer Prev Res (Phila). 2013 May;6(5):466-76. PMID: 23531445

"Design, Synthesis, and Structure-Activity Relationship Studies of Fluorescent Inhibitors of Cycloxygenase-2 as Targeted Optical Imaging Agents." Uddin J, Crews BA, Ghebreselasie K, Marnett LJ. Bioconjug Chem. 2013 Mar 15. [Epub ahead of print]

"Targeted protein capture for analysis of electrophile-protein adducts." Connor RE, Codreanu SG, Marnett LJ, Liebler DC. Methods Mol Biol. 2013;987:163-76. doi: 10.1007/978-1-62703-321-3_15. PMID: 23475677

"Development of Potent and Selective Indomethacin Analogs for the Inhibition of AKR1C3 (Type 5 17β-Hydroxysteroid Dehydrogenase/Prostaglandin F Synthase) in Castrate-Resistant Prostate Cancer." Liedtke AJ, Adeniji AO, Chen M, Byrns MC, Jin Y, Christianson DW, Marnett LJ, Penning TM. J Med Chem. 2013 Mar 13

"Cannabinoid receptor 1 suppresses transient receptor potential vanilloid 1-induced inflammatory responses to corneal injury," Yang Y, Yang H, Wang Z, Varadaraj K, Kumari SS, Mergler S, Okada Y, Saika S, Kingsley PJ, Marnett LJ, Reinach PS. Cell Signal. 2013 Feb;25(2):501-11

"The Stress Protein BAG3 Stabilizes Mcl-1 Protein and Promotes Survival of Cancer Cells and Resistance to Antagonist ABT-737." Boiani M, Daniel C, Liu X, Hogarty MD, Marnett LJ. J Biol Chem. 2013 Mar 8;288(10): 6980-90

"Cobalt Carbonyl Complexes as Probes for Alkyne-Tagged Lipids. Tallman KA, Armstrong MD, Milne SB, Marnett LJ, Brown HA, Porter NA," J Lipid Res. 2013 Jan 10. [Epub ahead of print] PMID: 23307946 

"Advancing the translation of optical imaging agents for clinical imaging," Sevick-Muraca EM, Akers WJ, Joshi BP, Luker GD, Cutler CS, Marnett LJ, Contag CH, Wang TD, Azhdarinia A. Biomed Opt Express. 2013 Jan 1;4(1):160-70

"2-Carbaborane-3-phenyl-1H-indoles-Synthesis via McMurry Reaction and Cyclooxygenase (COX) Inhibition Activity," Laube M, Neumann W, Scholz M, Lönnecke P, Crews B, Marnett LJ, Pietzsch J, Kniess T, Hey-Hawkins E. ChemMedChem. 2013 Feb;8(2):329-35

"Peptidyl-prolyl cis/trans-Isomerase A1 (Pin1) Is a Target for Modification by Lipid Electrophiles," Aluise CD, Rose K, Boiani M, Reyzer ML, Manna JD, Tallman K, Porter NA, Marnett LJ. Chem Res Toxicol. 2013 Feb 18;26(2):270-9

 

2012 Publications

"Straightforward protocol for the efficient synthesis of varied N(1)-acylated (aza)indole 2-/3-alkanoic acids and esters: optimization and scale-up," Liedtke AJ, Kim K, Stec DF, Sulikowski GA, Marnett LJ. Tetrahedron. 2012 Dec 2;68(48):10049-10058

"Single-dose safety and pharmacokinetic evaluation of fluorocoxib A: pilot study of novel cyclooxygenase-2-targeted optical imaging agent in a canine model," Cekanova M, Uddin MJ, Legendre AM, Galyon G, Bartges JW, Callens A, Martin-Jimenez T, Marnett LJ. J Biomed Opt. 2012 Nov;17(11):116002

"Substrate-Selective Inhibition of Cyclooxygenase-2: Development and Evaluation of Achiral Profen Probes," Windsor MA, Hermanson DJ, Kingsley PJ, Xu S, Crews BC, Ho W, Keenan CM, Banerjee S, Sharkey KA, Marnett LJ. ACS Med Chem Lett. 2012 Sep 13;3(9):759-763

"Prostaglandin H synthase-2-catalyzed oxygenation of 2-arachidonoylglycerol is more sensitive to peroxide tone than oxygenation of arachidonic acid," Musee J, Marnett LJ. J Biol Chem. 2012 Oct 26;287(44):37383-94

"Crystal structure of 12-lipoxygenase catalytic-domain-inhibitor complex identifies a substrate-binding channel for catalysis," Xu S, Mueser TC, Marnett LJ, Funk MO Jr. Structure. 2012 Sep 5;20(9):1490-7

"Ortho-carbaborane derivatives of indomethacin as cyclooxygenase (COX)-2 selective inhibitors," Scholz M, Blobaum AL, Marnett LJ, Hey-Hawkins E. Bioorg Med Chem. 2012 Aug 1;20(15):4830-7

"Seeing it through: translational validation of new medical imaging modalities," Aldrich MB, Marshall MV, Sevick-Muraca EM, Lanza G, Kotyk J, Culver J, Wang LV, Uddin J, Crews BC, Marnett LJ, Liao JC, Contag C, Crawford JM, Wang K, Reisdorph B, Appelman H, Turgeon DK, Meyer C, Wang T. Biomed Opt Express. 2012 Apr 1;3(4):764-76

"Protein modification by oxidized phospholipids and hydrolytically released lipid electrophiles: Investigating cellular responses," Ullery JC, Marnett LJ. Biochim Biophys Acta. 2012 Oct;1818(10):2424-35

"Inflammation and cancer: chemical approaches to mechanisms, imaging, and treatment," Marnett LJ. J Org Chem. 2012 Jun 15;77(12):5224-38

"Cyclooxygenase-1-selective inhibitors based on the (E)-2'-des-methyl-sulindac sulfide scaffold," Liedtke AJ, Crews BC, Daniel CM, Blobaum AL, Kingsley PJ, Ghebreselasie K, Marnett LJ. J Med Chem. 2012 Mar 8;55(5):2287-300. doi: 10.1021/jm201528b

"Total Synthesis (+)-7-Bromotrypargine and Unnatural Analogs: Biological Evaluation Uncovers Activity at CNS Targets of Therapeutic Relevance," Brogan JT, Stoops SL, Crews BC, Marnett LJ, Lindsley CW. ACS Chem Neurosci. 2011 Nov 16;2(11):633-639

"Selection of monoclonal antibodies against 6-oxo-M(1)dG and their use in an LC-MS/MS assay for the presence of 6-oxo-M(1)dG in vivo," Akingbade D, Kingsley PJ, Shuck SC, Cooper T, Carnahan R, Szekely J, Marnett LJ. Chem Res Toxicol. 2012 Feb 20;25(2):454-61