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MP&B 8327: Molecular Endocrinology


MP&B 8327. Molecular Endocrinology. A survey of the molecular biology of hormone action from the target cell surface to the nucleus. Special emphasis on (i) diabetes and obesity and (ii) how receptors and intracellular messengers mediate hormone action, (iii) how hormones regulate gene expression, and (iv) signaling in adipocytes. Discussion of the use of genetic, molecular biology, and biochemical techniques to study hormone action. The faculty encourage an interactive atmosphere in the class through the discussion of seminal papers. This is an advanced course so some prior background in cell signaling is recommended.



Time: Wednesday, 3-5pm
Location: 736 RRB
Credit: 2 hours
Information: Call Richard O’Brien at 936-1503/1629

Section 1: O’Brien

Aug. 24 Diabetes & insulin action
Aug. 31 Regulation of gene transcription & translation by insulin
Sept. 7 Paper discussion
Sept. 14 Paper discussion

Section 2: Colbran

Sept. 21 Lipolysis: HSL, ATGL, perilipin, and cAMP/PKA signaling
Sept. 28 Lipogenesis: phosphatases and insulin signaling in adipocytes
Oct. 5 AMPK signaling in adipocytes and beyond
Oct. 12 Exam

Section 3: Vickers/Niswender/Bingham

Oct. 19 Lipoprotein Metabolism and Cholesterol Homeostasis (Vickers)
Oct. 26 Energy homeostasis (Niswender)
Nov. 2 Pathophysiology of metabolic syndrome (Niswender)
Nov. 9 Novel Endocrine-like Communication Networks (Vickers)
Nov. 16 Neuropeptides (Bingham)
Nov. 23 No lecture – Thanksgiving
Nov. 30 The nuclear receptor superfamily (Bingham)
Dec. 7 Exam