This page is sparsely maintained and only students who have graduated since mid-2014 are listed. If you are a student alum and would like to be listed, please fill in this form.
- Graduate Student, Hong laboratory, Molecular Physiology & Biophysics
Titin, the largest known protein, is indispensable for the structural integrity and function of the cardiac sarcomere. Yet, how such a massive ~3 mDa structural protein is maintained within the highly ordered sarcomere complex, while under continuously alternating tension, is unknown. My thesis focuses on elucidating the mechanisms mediating sarcomere homeostasis in human induced pluripotent stem cell-derived cardiomyocytes. Using CRISPR/Cas9 gene editing, I generated a novel model in which I can directly visualize sarcomeric titin in order to address fundamental questions regarding titin turnover, which is critical for sarcomere homeostasis.
- Graduate Student, Maureen Gannon laboratory, Molecular Physiology & Biophysics
Prostaglandins are important modulators of an array of physiologic functions including insulin secretion and systemic inflammation. In the Gannon lab, I focus on the specific roles of the prostaglandin E2 receptors EP3 and EP4 and how they regulate processes involved in β-cell mass expansion. I am using pharmacological tools to examine the effects of EP3 and EP4 signaling in β-cell proliferation and β-cell survival in isolated mouse and human islets. I am also studying the effects of an EP3 antagonist and an EP4 agonist on β-cell proliferation and β-cell survival in the db/db mouse model of type 2 diabetes.7425C MRB IV(615) 936-2676
- Graduate Student, Peter Weil laboratory, Molecular Physiology & Biophysics
- Graduate Student, Powers laboratory, Molecular Physiology & Biophysics
My thesis in the Powers laboratory addresses basic questions of diabetes pathology, specifically (1) the functional consequences of chronic hyperglycemia on human pancreatic islets in vivo, and (2) the effects of ErbB growth factors on islet growth and function
- MD PhD Student, Cone laboratory, Molecular Physiology & Biophysics
In the Cone lab, I study the pathophysiology associated with deletion of the MC4R, the most common monogenetic obesity syndrome in man (1/5000 allele frequency). Using the mouse as a model organism, I am characterizing the cardiovascular, metabolic and energetic consequences that result from MC4R deletion. Observations from my research have furthered the need to identify and monitor patients with this distinct obesity syndrome.
More broadly, my research interests include: energy metabolism, mitochondrial physiology, cardiovascular pathophysiology, pharmicogenomics, and gene environment interactions.8435 MRB IV
- Graduate Student, McGuinness laboratory, Molecular Physiology & Biophysics
In the McGuinness lab, my long-term research objective involves elucidating the mechanisms whereby neuroendocrine function can be regulated by alterations in the inflammatory environment.
- Graduate Student, Stein laboratory, Molecular Physiology & Biophysics
In the Stein lab, I work on identifying co-regulators of Pdx-1 and their regulation of critical β-cell genes.
723 Light Hall
- Graduate Student, Weil Laboratory, Molecular Physiology & Biophysics
RNA Polymerase II transcriptional activation contributes importantly to the regulation of gene expression by controlling mRNA biosynthesis. A central driving force of the activation process is provided by the concerted action of a DNA-binding transfactor and at least one coactivator. I am interested in defining the transfactor-coactivator interactions required for activation. The specific goal of my current work in the Weil lab is to determine the specific domains the Rap1 transcriptional activator uses to interact with the general transcription factor TFIID to drive activation of the budding yeast S. cerevisiae ribosomal protein genes. I combine genetic, biochemical, and biophysical approaches to accomplish this goal.742 RRB(615) 322-7008
- MD PhD Student, Stafford lab, Molecular Physiology & Biophysics7445 MRB IV
- Graduate Student, Neurt laboratory, Molecular Physiology & Biophysics
- Graduate Student, O'Brien laboratory, Molecular Physiology & Biophysics
The prevalence type 2 diabetes (T2D) continues to increase worldwide. Multiple SNPs associated with altered risk of T2D have been identified through genome wide association studies including rs13266634 in the SLC30A8 locus, which encodes zinc transporter 8 (ZnT8). In addition, rare mutations resulting in SLC30A8 haploinsufficiency are protective against T2D. Using several mouse models, we are investigating the role that ZnT8 plays in beta cell function and the potential of ZnT8 as a therapeutic target for T2D.8415 MRB IV
- Research Fellow / Piston Lab, Molecular Physiology and Biophysics
Research Interest: I am currently investigating the function of dopamine in the pancreatic islets with the goal of understanding how observed dopaminergic feedback regulates glucose stimulated insulin secretion.747 Light Hall2215 Garland AvenueNashville 37232
- Graduate Student, Jacobson laboratory, Molecular Physiology & Biophysics
The deterioration of pancreatic islet function is a hallmark of type 2 diabetes mellitus (T2DM). In the Jacobson lab, I study the physiological functions of an islet potassium channel, TALK-1. TALK-1 is the most transcriptionally abundant potassium channel in insulin-secreting β-cells, and polymorphisms in TALK-1 are associated with an increased susceptibility for T2DM. However, the molecular mechanisms underlying TALK-1’s contributions to T2DM pathogenesis remain unclear. Using a variety of experimental approaches, including electrophysiology, calcium imaging, hormone secretion, and mouse models, we have recently found that TALK-1 channels regulate islet calcium homeostasis and insulin secretion. These findings suggest that TALK-1 could serve as a therapeutic target in T2DM.7415 MRB IV
- Graduate Student, Venters laboratory, Molecular Physiology & Biophysics746 RRB
- Graduate Student, Wasserman laboratory, Molecular Physiology & Biophysics823 Light Hall
- Graduate Student, Hawiger laboratory, Molecular Physiology & Biophysics