Bethany Carboneau, BA
Graduate Student, Maureen Gannon laboratory, Molecular Physiology & Biophysics
Prostaglandins are important modulators of an array of physiologic functions including insulin secretion and systemic inflammation. In the Gannon lab, I focus on the specific roles of the prostaglandin E2 receptors EP3 and EP4 and how they regulate processes involved in β-cell mass expansion. I am using pharmacological tools to examine the effects of EP3 and EP4 signaling in β-cell proliferation and β-cell survival in isolated mouse and human islets. I am also studying the effects of an EP3 antagonist and an EP4 agonist on β-cell proliferation and β-cell survival in the db/db mouse model of type 2 diabetes.