Molecular mechanisms of inherited cardiomyopathies.
Our lab studies the genetic pathways that cause inherited cardiomyopathies in humans in an effort to identify novel methods to prevent and treat heart failure. We utilize a variety of experimental systems which include mammalian cell culture, vertebrate model organisms, and human samples.
The primary goals of the lab are:
• Identify genetic pathways involved in the pathogenesis of inherited cardiomyopathies in humans.
• Develop methods to study these pathways using both in vitro and in vivo experimental model systems.
• Identify chemical modifiers of these disease pathways which can serve as the foundation for novel therapeutic strategies.