My thesis research aims to investigate how G protein-coupled receptors (GPCRs) regulate the trafficking of a novel ion channel, Kir7.1. Our lab has found that the GPCR melanocortin 4 receptor (MC4R), interacts with the Kir7.1 inwardly rectifying potassium channel to regulate energy homeostasis. We have found that MC4R can modulate the activity of Kir7.1 independent of G-proteins, and my project seeks to identify the molecular basis for this interaction.
Graduate Student, Cone and Mchaourab Laboratories, Molecular Physiology & Biophysics
8435 MRB IV