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Molecular Physiology & Biophysics

Activation of NF-κB drives the enhanced survival of adipose tissue macrophages in an obesogenic environment.

AUTHORS

Hill AA , Anderson-Baucum EK , Kennedy AJ , Webb CD , Yull FE , Hasty AH , . Molecular metabolism. 2015 10 ; 4(10). 665-77

ABSTRACT

Macrophage accumulation in adipose tissue (AT) during obesity contributes to inflammation and insulin resistance. Recruitment of monocytes to obese AT has been the most studied mechanism explaining this accumulation. However, recent evidence suggests that recruitment-independent mechanisms may also regulate pro-inflammatory AT macrophage (ATM) numbers. The role of increased ATM survival during obesity has yet to be explored.

Macrophage accumulation in adipose tissue (AT) during obesity contributes to inflammation and insulin resistance. Recruitment of monocytes to obese AT has been the most studied mechanism explaining this accumulation. However, recent evidence suggests that recruitment-independent mechanisms may also regulate pro-inflammatory AT macrophage (ATM) numbers. The role of increased ATM survival during obesity has yet to be explored.

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