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Assignment of the molecular origins of CEST signals at 2 ppm in rat brain.


AUTHORS

Zhang XY , Xie J , Wang F , Lin EC , Xu J , Gochberg DF , Gore JC , Zu Z , . Magnetic resonance in medicine. 2017 9 ; 78(3). 881-887

ABSTRACT

Chemical exchange saturation transfer effects at 2 ppm (CEST@2ppm) in brain have previously been interpreted as originating from creatine. However, protein guanidino amine protons may also contribute to CEST@2ppm. This study aims to investigate the molecular origins and specificity of CEST@2ppm in brain.


Chemical exchange saturation transfer effects at 2 ppm (CEST@2ppm) in brain have previously been interpreted as originating from creatine. However, protein guanidino amine protons may also contribute to CEST@2ppm. This study aims to investigate the molecular origins and specificity of CEST@2ppm in brain.


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