Association of Long Runs of Homozygosity With Alzheimer Disease Among African American Individuals.
AUTHORS
Ghani
M ,
Reitz
C ,
Cheng
R ,
Vardarajan
BN ,
Jun
G ,
Sato
C ,
Naj
A ,
Rajbhandary
R ,
Wang
LS ,
Valladares
O ,
Lin
CF ,
Larson
EB ,
Graff-Radford
NR ,
Evans
D ,
De Jager
PL ,
Crane
PK ,
Buxbaum
JD ,
Murrell
JR ,
Raj
T ,
Ertekin-Taner
N ,
Logue
M ,
Baldwin
CT ,
Green
RC ,
Barnes
LL ,
Cantwell
LB ,
Fallin
MD ,
Go
RC ,
Griffith
PA ,
Obisesan
TO ,
Manly
JJ ,
Lunetta
KL ,
Kamboh
MI ,
Lopez
OL ,
Bennett
DA ,
Hendrie
H ,
Hall
KS ,
Goate
AM ,
Byrd
GS ,
Kukull
WA ,
Foroud
TM ,
Haines
JL ,
Farrer
LA ,
Pericak-Vance
MA ,
Lee
JH ,
Schellenberg
GD ,
St George-Hyslop
P ,
Mayeux
R ,
Rogaeva
E ,
,
. JAMA neurology. 2015 11 ; 72(11). 1313-23
- PMID: 26366463 [PubMed].
- PMCID: PMC4641052.
- NIHMSID: NIHMS726865
ABSTRACT
Mutations in known causal Alzheimer disease (AD) genes account for only 1% to 3% of patients and almost all are dominantly inherited. Recessive inheritance of complex phenotypes can be linked to long (>1-megabase [Mb]) runs of homozygosity (ROHs) detectable by single-nucleotide polymorphism (SNP) arrays.
Mutations in known causal Alzheimer disease (AD) genes account for only 1% to 3% of patients and almost all are dominantly inherited. Recessive inheritance of complex phenotypes can be linked to long (>1-megabase [Mb]) runs of homozygosity (ROHs) detectable by single-nucleotide polymorphism (SNP) arrays.
Tags: 2015