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Molecular Physiology & Biophysics

Effects of Multiple Genetic Loci on Age at Onset in Late-Onset Alzheimer Disease: A Genome-Wide Association Study.

AUTHORS

Naj AC , Jun G , Reitz C , Kunkle BW , Perry W , Park YS , Beecham GW , Rajbhandary RA , Hamilton-Nelson KL , Wang LS , Kauwe JS , Huentelman MJ , Myers AJ , Bird TD , Boeve BF , Baldwin CT , Jarvik GP , Crane PK , Rogaeva E , Barmada MM , Demirci FY , Cruchaga C , Kramer PL , Ertekin-Taner N , Hardy J , Graff-Radford NR , Green RC , Larson EB , St George-Hyslop PH , Buxbaum JD , Evans DA , Schneider JA , Lunetta KL , Kamboh MI , Saykin AJ , Reiman EM , De Jager PL , Bennett DA , Morris JC , Montine TJ , Goate AM , Blacker D , Tsuang DW , Hakonarson H , Kukull WA , Foroud TM , Martin ER , Haines JL , Mayeux RP , Farrer LA , Schellenberg GD , Pericak-Vance MA , , . JAMA neurology. 2014 9 8; ().

ABSTRACT

Because APOE locus variants contribute to risk of late-onset Alzheimer disease (LOAD) and to differences in age at onset (AAO), it is important to know whether other established LOAD risk loci also affect AAO in affected participants.

Because APOE locus variants contribute to risk of late-onset Alzheimer disease (LOAD) and to differences in age at onset (AAO), it is important to know whether other established LOAD risk loci also affect AAO in affected participants.

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