Gcgknockin mice as a tool for genetic manipulation in pancreatic alpha cells.
AUTHORS
Shiota
C ,
Prasadan
K ,
Guo
P ,
Fusco
J ,
Xiao
X ,
Gittes
GK ,
. Diabetologia. 2017 12 ; 60(12). 2399-2408
- PMID: 28884202 [PubMed].
- PMCID: PMC5671347.
- NIHMSID: NIHMS904869
ABSTRACT
The Cre/loxP system, which enables tissue-specific manipulation of genes, is widely used in mice for diabetes research. Our aim was to develop a new Cre-driver mouse line for the specific and efficient manipulation of genes in pancreatic alpha cells.
The Cre/loxP system, which enables tissue-specific manipulation of genes, is widely used in mice for diabetes research. Our aim was to develop a new Cre-driver mouse line for the specific and efficient manipulation of genes in pancreatic alpha cells.
Tags: 2017