- Adi N, Perriotte-Olson C, Desouza CV, Ramalingam R, Saraswathi V. Hematopoietic cyclooxygenase-2 deficiency increases adipose tissue inflammation and adiposity in obesity. Obesity (Silver Spring, Md.). 2015 Oct;23(10). 2037-45. PMID: 26316178 [PubMed].
Adipose tissue (AT) macrophages mediate AT inflammation in obesity, and cyclooxygenase-2 (COX-2) is a major inflammatory gene. It was hypothesized that deletion of hematopoietic COX-2 will inhibit AT inflammation in obesity.