Hematopoietic cyclooxygenase-2 deficiency increases adipose tissue inflammation and adiposity in obesity.
AUTHORS
Adi
N ,
Perriotte-Olson
C ,
Desouza
CV ,
Ramalingam
R ,
Saraswathi
V ,
. Obesity (Silver Spring, Md.). 2015 10 ; 23(10). 2037-45
- PMID: 26316178 [PubMed].
ABSTRACT
Adipose tissue (AT) macrophages mediate AT inflammation in obesity, and cyclooxygenase-2 (COX-2) is a major inflammatory gene. It was hypothesized that deletion of hematopoietic COX-2 will inhibit AT inflammation in obesity.
Adipose tissue (AT) macrophages mediate AT inflammation in obesity, and cyclooxygenase-2 (COX-2) is a major inflammatory gene. It was hypothesized that deletion of hematopoietic COX-2 will inhibit AT inflammation in obesity.
Tags: 2015