• Haase VH. Inflammation and hypoxia in the kidney: friends or foes? Kidney international. 2015 Aug;88(2). 213-5. PMID: 26230196 [PubMed]. PMCID: PMC4534718. NIHMSID: NIHMS712830.


Hypoxic injury is commonly associated with inflammatory-cell infiltration, and inflammation frequently leads to the activation of cellular hypoxia response pathways. The molecular mechanisms underlying this cross-talk during kidney injury are incompletely understood. Yamaguchi and colleagues identify CCAAT/enhancer-binding protein δ as a cytokine- and hypoxia-regulated transcription factor that fine-tunes hypoxia-inducible factor-1 signaling in renal epithelial cells and thus provide a novel molecular link between hypoxia and inflammation in kidney injury.