Inhibition of Interleukin 17-A but not Interleukin-17F Signaling Lowers Blood Pressure and Reduces End-organ Inflammation in Angiotensin II-induced Hypertension.
AUTHORS
Saleh
MA ,
Norlander
AE ,
Madhur
MS ,
. JACC. Basic to translational science. 2016 12 ; 1(7). 606-616
- PMID: 28280792 [PubMed].
- PMCID: PMC5337944.
- NIHMSID: NIHMS814833
ABSTRACT
To characterize the T cell subsets producing interleukin 17 (IL-17) isoforms A and F in hypertensive kidneys and vessels and determine whether inhibition of IL-17 signaling lowers blood pressure and end-organ damage in a mouse model of hypertension.
To characterize the T cell subsets producing interleukin 17 (IL-17) isoforms A and F in hypertensive kidneys and vessels and determine whether inhibition of IL-17 signaling lowers blood pressure and end-organ damage in a mouse model of hypertension.
Tags: 2016