• Harkins KD, Xu J, Dula AN, Li K, Valentine WM, Gochberg DF, Gore JC, Does MD. The microstructural correlates of T1 in white matter. Magnetic resonance in medicine. 2016 Mar;75(3). 1341-5. PMID: 25920491 [PubMed]. PMCID: PMC4624612. NIHMSID: NIHMS678390.


Several studies have shown strong correlations between myelin content and T1 within the brain, and have even suggested that T1 can be used to estimate myelin content. However, other micro-anatomical features such as compartment size are known to affect longitudinal relaxation rates, similar to compartment size effects in porous media.