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Molecular Physiology & Biophysics

Mitochondrial Haplogroups Affect Severity But Not Prevalence of Diabetic Retinopathy.

AUTHORS

Bregman JA , Herren DJ , Estopinal CB , Chocron IM , Harlow PA , Warden C , Brantley MA , Samuels DC , . Investigative ophthalmology & visual science. 2017 2 1; 58(2). 1346-1351

ABSTRACT

We previously reported European mitochondrial haplogroup H to be a risk factor for and haplogroup UK to be protective against proliferative diabetic retinopathy (PDR) among Caucasian patients with diabetic retinopathy (DR). The purpose of this study was to determine whether these haplogroups are also associated with the risk of having DR among Caucasian patients with diabetes.

We previously reported European mitochondrial haplogroup H to be a risk factor for and haplogroup UK to be protective against proliferative diabetic retinopathy (PDR) among Caucasian patients with diabetic retinopathy (DR). The purpose of this study was to determine whether these haplogroups are also associated with the risk of having DR among Caucasian patients with diabetes.

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