Pleiotropic and sex-specific effects of cancer GWAS SNPs on melanoma risk in the population architecture using genomics and epidemiology (PAGE) study.
AUTHORS
Kocarnik
JM ,
Park
SL ,
Han
J ,
Dumitrescu
L ,
Cheng
I ,
Wilkens
LR ,
Schumacher
FR ,
Kolonel
L ,
Carlson
CS ,
Crawford
DC ,
Goodloe
RJ ,
Dilks
HH ,
Baker
P ,
Richardson
D ,
Matise
TC ,
Ambite
JL ,
Song
F ,
Qureshi
AA ,
Zhang
M ,
Duggan
D ,
Hutter
C ,
Hindorff
L ,
Bush
WS ,
Kooperberg
C ,
Le Marchand
L ,
Peters
U ,
. PloS one. 2015 ; 10(3). e0120491
- PMID: 25789475 [PubMed].
- PMCID: PMC4366224.
ABSTRACT
Several regions of the genome show pleiotropic associations with multiple cancers. We sought to evaluate whether 181 single-nucleotide polymorphisms previously associated with various cancers in genome-wide association studies were also associated with melanoma risk.
Several regions of the genome show pleiotropic associations with multiple cancers. We sought to evaluate whether 181 single-nucleotide polymorphisms previously associated with various cancers in genome-wide association studies were also associated with melanoma risk.
Tags: 2015