• Bingham NC, Cone RD. Regulation of orexigenic AgRP neurons: A third way? Trends in endocrinology and metabolism: TEM. 2015 Jul;26(7). 339-40. PMID: 26033032 [PubMed].


Arcuate AgRP neurons are critical for food intake. Two pathways leading to AgRP neuron activation and food intake include regulation by peripheral hormones leptin and ghrelin, and neuronal regulation via glutamatergic inputs. In a recent article in Cell Reports, Yang et al. demonstrate 'a third way,' regulation by resident astrocytes.