Skip to main content

Molecular Physiology & Biophysics

Role of Striatal Direct Pathway 2-Arachidonoylglycerol Signaling in Sociability and Repetitive Behavior.

AUTHORS

Shonesy BC , Parrish WP , Haddad HK , Stephenson JR , Báldi R , Bluett RJ , Marks CR , Centanni SW , Folkes OM , Spiess K , Augustin SM , Mackie K , Lovinger DM , Winder DG , Patel S , Colbran RJ , . Biological psychiatry. 2017 12 28; ().

ABSTRACT

Endocannabinoid signaling plays an important role in regulating synaptic transmission in the striatum, a brain region implicated as a central node of dysfunction in autism spectrum disorder. Deficits in signaling mediated by the endocannabinoid 2-arachidonoylglycerol (2-AG) have been reported in mouse models of autism spectrum disorder, but a causal role for striatal 2-AG deficiency in phenotypes relevant to autism spectrum disorder has not been explored.

Endocannabinoid signaling plays an important role in regulating synaptic transmission in the striatum, a brain region implicated as a central node of dysfunction in autism spectrum disorder. Deficits in signaling mediated by the endocannabinoid 2-arachidonoylglycerol (2-AG) have been reported in mouse models of autism spectrum disorder, but a causal role for striatal 2-AG deficiency in phenotypes relevant to autism spectrum disorder has not been explored.

Tags: