Site-specific selection reveals selective constraints and functionality of tumor somatic mtDNA mutations.
AUTHORS
Li
D ,
Du
X ,
Guo
X ,
Zhan
L ,
Li
X ,
Yin
C ,
Chen
C ,
Li
M ,
Li
B ,
Yang
H ,
Xing
J ,
. Journal of experimental & clinical cancer research : CR. 2017 11 28; 36(1). 168
- PMID: 29179728 [PubMed].
- PMCID: PMC5704541.
ABSTRACT
Previous studies have indicated that tumor mitochondrial DNA (mtDNA) mutations are primarily shaped by relaxed negative selection, which is contradictory to the critical roles of mtDNA mutations in tumorigenesis. Therefore, we hypothesized that site-specific selection may influence tumor mtDNA mutations.
Previous studies have indicated that tumor mitochondrial DNA (mtDNA) mutations are primarily shaped by relaxed negative selection, which is contradictory to the critical roles of mtDNA mutations in tumorigenesis. Therefore, we hypothesized that site-specific selection may influence tumor mtDNA mutations.
Tags: 2017