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Molecular Physiology & Biophysics

Towards a phenome-wide catalog of human clinical traits impacted by genetic ancestry.

AUTHORS

Dumitrescu L , Restrepo NA , Goodloe R , Boston J , Farber-Eger E , Pendergrass SA , Bush WS , Crawford DC , . BioData mining. 2015 ; 8(). 35

ABSTRACT

Racial/ethnic differences for commonly measured clinical variables are well documented, and it has been postulated that population-specific genetic factors may play a role. The genetic heterogeneity of admixed populations, such as African Americans, provides a unique opportunity to identify genomic regions and variants associated with the clinical variability observed for diseases and traits across populations.

Racial/ethnic differences for commonly measured clinical variables are well documented, and it has been postulated that population-specific genetic factors may play a role. The genetic heterogeneity of admixed populations, such as African Americans, provides a unique opportunity to identify genomic regions and variants associated with the clinical variability observed for diseases and traits across populations.

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