Dysregulated transcription across diverse cancer types reveals the importance of RNA-binding protein in carcinogenesis.
AUTHORS
- PMID: PMC4474540 [PubMed].
- PMCID: PMC4474540.
- NIHMSID: 100965258
ABSTRACT
It is well known that carcinogenesis is in part dictated by dysregulated transcription events and signal pathways. Large-scale transcriptional profiling studies in each cancer type have reported aberrant gene expression associated with cancer development. However, common and specific patterns altered across cancer types, especially the contribution of transcriptional and post-transcriptional regulators, are rarely explored.
It is well known that carcinogenesis is in part dictated by dysregulated transcription events and signal pathways. Large-scale transcriptional profiling studies in each cancer type have reported aberrant gene expression associated with cancer development. However, common and specific patterns altered across cancer types, especially the contribution of transcriptional and post-transcriptional regulators, are rarely explored.
Tags: Faculty Publications 2015