• Wiese AD, Griffin MR, Stein CM, Mitchel EF, Grijalva CG. Opioid analgesics and the risk of serious infections among patients with rheumatoid arthritis: A self-controlled case series study. Arthritis & rheumatology (Hoboken, N.J.). 2015 Oct 16. PMID: 26473742 [PubMed].

Abstract 

Animal and in vitro studies suggest that certain opioid analgesics impair crucial immune functions. We sought to determine if opioid use is associated with an increased risk of serious infections in patients with rheumatoid arthritis (RA).