Skip to main content

Master of Public Health

Residual sympathetic tone is associated with reduced insulin sensitivity in patients with autonomic failure.

AUTHORS

Celedonio JE , Arnold AC , Dupont WD , Ramirez CE , Diedrich A , Okamoto LE , Raj SR , Robertson D , Peltier AC , Biaggioni I , Shibao CA , . Clinical autonomic research : official journal of the Clinical Autonomic Research Society. 2015 9 10; ().
  • NIHMSID: 9106549

ABSTRACT

Parkinson disease, an α-synucleinopathy, is associated with reduced insulin sensitivity, impaired glucose tolerance, and diabetes mellitus. Importantly, these metabolic alterations have been shown to contribute to disease progression. The purpose of this study was to determine if reduced insulin sensitivity is also present in other α-synucleinopathies associated with autonomic failure.

Parkinson disease, an α-synucleinopathy, is associated with reduced insulin sensitivity, impaired glucose tolerance, and diabetes mellitus. Importantly, these metabolic alterations have been shown to contribute to disease progression. The purpose of this study was to determine if reduced insulin sensitivity is also present in other α-synucleinopathies associated with autonomic failure.

Tags: