- Murff HJ, Roumie CL, Greevy RA, Grijalva CG, Hung AH, Liu X, Griffin MR. Thiazolidinedione and Metformin Use and the Risk of Benign Prostate Hyperplasia in Veterans with Diabetes Mellitus. Journal of men's health. 2014 Dec 1;11(4). 157-162. PMID: 25798210 [PubMed]. PMCID: PMC4364420. NIHMSID: NIHMS666838.
Chronic inflammation is important in the development of benign prostatic hyperplasia (BPH) and certain oral antidiabetic medications have anti-inflammatory properties. The purpose of this study was to determine if use of thiazolidinediones or metformin was associated with a reduced risk of requiring medical or surgical treatment for BPH compared to sulfonylureas among diabetic men.