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Trimethoprim-sulfonamide use during the first trimester of pregnancy and the risk of congenital anomalies.


AUTHORS

Hansen C , Andrade SE , Freiman H , Dublin S , Haffenreffer K , Cooper WO , Cheetham TC , Toh S , Li DK , Raebel MA , Kuntz JL , Perrin N , Rosales AG , Carter S , Pawloski PA , Maloney EM , Graham DJ , Sahin L , Scott PE , Yap J , Davis R , . Pharmacoepidemiology and drug safety. 2015 11 24; ().
  • NIHMSID: 9208369

ABSTRACT

Sulfonamide antibacterials are widely used in pregnancy, but evidence about their safety is mixed. The objective of this study was to assess the association between first-trimester sulfonamide exposure and risk of specific congenital malformations.


Sulfonamide antibacterials are widely used in pregnancy, but evidence about their safety is mixed. The objective of this study was to assess the association between first-trimester sulfonamide exposure and risk of specific congenital malformations.


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