• Murphy AJ, Pierce J, Seeley EH, Sullivan LM, Ruchelli ED, Nance ML, Caprioli RM, Lovvorn HN. Peptide spectra in Wilms tumor that associate with adverse outcomes. The Journal of surgical research. 2015 Jun 15;196(2). 332-8. PMID: 25868780 [PubMed]. PMCID: PMC4599776. NIHMSID: NIHMS673253.


The 2013 Children's Oncology Group (COG) blueprint for renal tumor research challenges investigators to develop new, risk-specific biological therapies for unfavorable histology and higher-risk Wilms tumor (WT) in an effort to close a persistent survival gap and to reduce treatment toxicities. As an initial response to this call from the COG, we used imaging mass spectrometry to determine peptide profiles of WT associated with adverse outcomes.