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MSTPublications: June 2018

Posted by on Wednesday, June 27, 2018 in New Publications .

Congratulations to all of our MSTP students on their successful publications! Take a look at the great work our students are doing.

First Author Ph.D. Research:

Learning Implicit Brain MRI Manifolds with Deep Learning.
Bermudez C, Plassard AJ, Davis TL, Newton AT, Resnick SM, Landman BA.
Proc SPIE Int Soc Opt Eng. 2018 Mar;10574. pii: 105741L. doi: 10.1117/12.2293515.

An important task in image processing and neuroimaging is to extract quantitative information from the acquired images in order to make observations about the presence of disease or markers of development in populations. Having a low-dimensional manifold of an image allows for easier statistical comparisons between groups and the synthesis of group representatives. In this work, we use deep learning techniques to investigate implicit manifolds of normal brains and generate new, high-quality images. We explore implicit manifolds by addressing the problems of image synthesis and image denoising as important tools in manifold learning. Synthesized images were first shown to be unique by performing a cross-correlation with the training set. The quality score of the synthetic image showed substantial overlap with that of the real images. This work shows the power of artificial networks to synthesize realistic imaging data, which can be used to improve image processing techniques and provide a quantitative framework to structural changes in the brain. (By Cam Bermudez, G2)

 

Co-authorships, Clinical Studies, and Reviews:

A Data Colocation Grid Framework for Big Data Medical Image Processing: Backend Design.
Bao S, Huo Y, Parvathaneni P, Plassard AJ, Bermudez C, Yao Y, Lyu I, Gokhale A, Landman BA.
Proc SPIE Int Soc Opt Eng. 2018 Mar;10597. pii: 105790A. doi: 10.1117/12.2293694.

Splenomegaly Segmentation using Global Convolutional Kernels and Conditional Generative Adversarial Networks.
Huo Y, Xu Z, Bao S, Bermudez C, Plassard AJ, Liu J, Yao Y, Assad A, Abramson RG, Landman BA.
Proc SPIE Int Soc Opt Eng. 2018 Mar;10574. pii: 1057409. doi: 10.1117/12.2293406.

Psychosocial Difficulties in Adolescent Idiopathic Scoliosis: Body Image, Eating Behaviors, and Mood Disorders.
Gallant JN
, Morgan CD, Stoklosa JB, Gannon SR, Shannon CN, Bonfield CM.
World Neurosurg. 2018 May 23. pii: S1878-8750(18)31057-X. doi: 10.1016/j.wneu.2018.05.104. [Epub ahead of print] Review.

Relating structural and functional brainstem connectivity to disease measures in epilepsy.
Englot DJ, Gonzalez HFJ, Reynolds BB, Konrad PE, Jacobs ML, Gore JC, Landman BA, Morgan VL.
Neurology. 2018 May 30. pii: 10.1212/WNL.0000000000005733. doi: 10.1212/WNL.0000000000005733. [Epub ahead of print]

Read more about this paper here!

MLKL Requires the Inositol Phosphate Code to Execute Necroptosis.
Dovey CM, Diep J, Clarke BP, Hale AT, McNamara DE, Guo H, Brown NW Jr, Cao JY, Grace CR, Gough PJ, Bertin J, Dixon SJ, Fiedler D, Mocarski ES, Kaiser WJ, Moldoveanu T, York JD, Carette JE.
Mol Cell. 2018 Jun 7;70(5):936-948.e7. doi: 10.1016/j.molcel.2018.05.010. Epub 2018 Jun 7.

Synaptic Plasticity in the Bed Nucleus of the Stria Terminalis: Underlying Mechanisms and Potential Ramifications for Reinstatement of Drug- and Alcohol-Seeking Behaviors.
Harris NA, Winder DG.
ACS Chem Neurosci. 2018 Jun 13. doi: 10.1021/acschemneuro.8b00169. [Epub ahead of print]

BVES is required for maintenance of colonic epithelial integrity in experimental colitis by modifying intestinal permeability.
Choksi YA, Reddy VK, Singh K, Barrett CW, Short SP, Parang B, Keating CE, Thompson JJ, Verriere TG, Brown RE, Piazuelo MB, Bader DM, Washington MK, Mittal MK, Brand T, Gobert AP, Coburn LA, Wilson KT, Williams CS.
Mucosal Immunol. 2018 Jun 15. doi: 10.1038/s41385-018-0043-2. [Epub ahead of print]

A Phenome-Wide Association Study Uncovers a Role for Autoimmunity in the Development of Chronic Obstructive Pulmonary Disease.
Ji X, Niu X, Qian J,
Martucci V, Pendergrass SA, Gorlov IP, Amos CI, Denny JC, Massion PP, Aldrich MC.
Am J Respir Cell Mol Biol. 2018 Jun;58(6):777-779. doi: 10.1165/rcmb.2017-0409LE.

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