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MSTPublications: September 2020

Posted by on Monday, September 28, 2020 in New Publications.

Reconstruction of Upper Third Ear Defects: Utility of a Limited Tanzer Reduction.
Colazo JM, Farinas AF, Leonhard V, Valmadrid A, Kaoutzanis C, Thayer WP.
World J Plast Surg. 2020 May;9(2):179-185. doi: 10.29252/wjps.9.2.179.
PMID: 32934930

Background: Large ear defects (>3 cm) present a significant reconstructive challenge and often require extensive operations, which can lead to donor-site morbidity and contour abnormalities. Through our case series, we propose a limited Tanzer reduction, a novel modification of the well-recognized Tanzer technique, as a potential reconstructive option for traumatic and oncologic upper third ear defects.
Methods: We retrospectively reviewed patients who underwent planned ear reconstruction for large ear defects (>3 cm) at a university center by a single surgeon (WPT) over a five-year period. Demographics, complications, and need for revision surgery were recorded. A satisfaction survey was also completed.
Results: Five patients met our inclusion criteria as they underwent ear reconstruction with the limited Tanzer reduction. All reconstructions followed oncologic resection for cutaneous malignancy. The mean follow-up was 760.2 days. No complications were encountered, and no revisions were required. All cases had good aesthetic outcomes. The satisfaction survey revealed no self-image distortion or social obstacles following the reconstruction.
Conclusion: The proposed limited Tanzer reduction technique was shown to be a safe, viable, functionally and aesthetically pleasing option for the reconstruction of large defects of the ear and thus should be part of the armamentarium of the reconstructive surgeon.

Interpersonal reactivity index adaptation among expectant seroconcordant couples with HIV in Zambézia Province, Mozambique.
Sack DE, Frisby MB, Diemer MA, De Schacht C, Graves E, Kipp AM, Emílio A, Matino A, Barreto E, Van Rompaey S, Wallston KA, Audet CM.
BMC Psychol. 2020 Aug 28;8(1):90. doi: 10.1186/s40359-020-00442-0.
PMID: 32859272

Background: The ability to understand another’s emotions and act appropriately, empathy, is an important mediator of relationship function and health intervention fidelity. We adapted the Interpersonal Reactivity Index (IRI) – an empathy scale – among seroconcordant expectant couples with HIV in the Homens para Saúde Mais (HoPS+) trial – a cluster randomized controlled trial assessing couple-based versus individual treatment on viral suppression – in Zambézia Province, Mozambique.
Methods: Using baseline data from 1332 HoPS+ trial participants (666 couples), an exploratory factor analysis assessed culturally relevant questions from the IRI. Because empathy is interdependent among couples, we validated the results of the exploratory factor analysis using a dyadic confirmatory factor analysis (CFA) with dyadic measurement invariance testing. Finally, we assessed the relationship between scores on our final scale and basic demographic characteristics (sex, age, education, and depression) using t-tests.
Results: We found two subscales: 1) a seven-item cognitive empathy subscale (Cronbach’s alpha 0.78) and 2) a six-item affective empathy subscale (Cronbach’s alpha 0.73). The dyadic CFA found acceptable model fit and metric invariance across partners (Comparative Fit Index (CFI) = 0.914, Tucker Lewis Index = 0.904, Root Mean Squared Error of Approximation = 0.056, ΔCFI = 0.011). We observed higher cognitive (p: 0.012) and affective (p: 0.049) empathy among males and higher cognitive (p: 0.031) and affective (p: 0.030) empathy among younger participants. More educated participants had higher affective empathy (p: 0.017) and depressed participants had higher cognitive empathy (p: < 0.001). This two-subscale, 13-item version of the IRI measures cognitive and affective empathy in HoPS+ trial participants and adults while accounting for the interdependent nature of empathy within partner dyads.
Conclusions: This scale will allow us to assess the interplay between empathy and other psychometric constructs (stigma, social support, etc.) in the HoPS+ trial and how each relates to retention in HIV, adherence to treatment, and prevention of maternal to child HIV transmission. Furthermore, this scale can be adapted for other sub-Saharan African populations, which will allow researchers to better assess HIV-related intervention efficacy.

Measuring Depression in Autistic Adults: Psychometric Validation of the Beck Depression Inventory-II.
Williams ZJ, Everaert J, Gotham KO.
Assessment. 2020 Aug 29:1073191120952889. doi: 10.1177/1073191120952889. Online ahead of print.
PMID: 32864993

Depressive disorders are common in autistic adults, but few studies have examined the extent to which common depression questionnaires are psychometrically appropriate for use in this population. Using item response theory, this study examined the psychometric properties of the Beck Depression Inventory-II (BDI-II) in a sample of 947 autistic adults. BDI-II latent trait scores exhibited strong reliability, construct validity, and moderate ability to discriminate between depressed and nondepressed adults on the autism spectrum (area under the receiver operating characteristic curve = 0.796 [0.763, 0.826], sensitivity = 0.820 [0.785, 0.852], specificity = 0.653 [0.601, 0.699]). These results collectively indicate that the BDI-II is a valid measure of depressive symptoms in autistic adults, appropriate for quantifying depression severity in research studies or screening for depressive disorders in clinical settings. A free online score calculator has been created to facilitate the use of BDI-II latent trait scores for clinical and research applications

Anatomical Context Protects Deep Learning from Adversarial Perturbations in Medical Imaging.
Li Y, Zhang H, Bermudez C, Chen Y, Landman BA, Vorobeychik Y.
Neurocomputing. 2020 Feb 28;379:370-378. doi: 10.1016/j.neucom.2019.10.085. Epub 2019 Oct 31.

Accelerated brain aging predicts impaired cognitive performance and greater disability in geriatric but not midlife adult depression.
Christman S, Bermudez C, Hao L, Landman BA, Boyd B, Albert K, Woodward N, Shokouhi S, Vega J, Andrews P, Taylor WD.
Transl Psychiatry. 2020 Sep 18;10(1):317. doi: 10.1038/s41398-020-01004-z.
PMID: 32948749

A commentary on: ‘3D printing for developing patient specific cosmetic prosthetics at the point of care’
Colazo JM Mr, Koshy K Mr.
Int J Surg. 2020 Aug 22:S1743-9191(20)30625-7. doi: 10.1016/j.ijsu.2020.08.022. Online ahead of print. PMID: 32841727

Aerobic exercise training improves hepatic and muscle insulin sensitivity, but reduces splanchnic glucose uptake in obese humans with type 2 diabetes.
Gregory JM, Muldowney JA, Engelhardt BG, Tyree R, Marks-Shulman P, Silver HJ, Donahue EP, Edgerton DS, Winnick JJ.
Nutr Diabetes. 2019 Sep 2;9(1):25. doi: 10.1038/s41387-019-0090-0.
PMID: 31474750

Optimal Trajectory and Length of S2 Alar Iliac Screws: A 3-Dimensional Computed-aided Design Study.
Weisenthal BM, Doss DJ, Henry AL, Stephens BF.
Clin Spine Surg. 2019 Aug;32(7):E335-E339. doi: 10.1097/BSD.0000000000000837.
PMID: 31162183

Seizure-onset regions demonstrate high inward directed connectivity during resting-state: An SEEG study in focal epilepsy.
Narasimhan S, Kundassery KB, Gupta K, Johnson GW, Wills KE, Goodale SE, Haas K, Rolston JD, Naftel RP, Morgan VL, Dawant BM, González HFJ, Englot DJ.
Epilepsia. 2020 Sep 18. doi: 10.1111/epi.16686. Online ahead of print.
PMID: 32944945

Synthesis and Multiplexed Activity Profiling of Synthetic Acylphloroglucinol Scaffolds.
Porco J, Bachmann B, Boyce J, Reisman B.
Angew Chem Int Ed Engl. 2020 Sep 23. doi: 10.1002/anie.202010338. Online ahead of print.
PMID: 32965753

Hippocampal volume in early psychosis: a 2-year longitudinal study.
McHugo M, Armstrong K, Roeske MJ, Woodward ND, Blackford JU, Heckers S.
Transl Psychiatry. 2020 Sep 1;10(1):306. doi: 10.1038/s41398-020-00985-1.

Critical role of Interleukin 21 and T follicular helper cells in hypertension and vascular dysfunction.
Dale BL, Pandey AK, Chen Y, Smart CD, Laroumanie F, Ao M, Xiao L, Dikalova AE, Dikalov SI, Elijovich F, Foss JD, Barbaro NR, Van Beusecum JP, Deger SM, Alsouqi A, Itani HA, Norlander AE, Alexander MR, Zhao S, Ikizler TA, Algood HMS, Madhur MS.
JCI Insight. 2019 Apr 23;5(11):e129278. doi: 10.1172/jci.insight.129278.
PMID: 31013256 

Sign Inversion in Photopharmacology: Incorporation of Cyclic Azobenzenes in Photoswitchable Potassium Channel Blockers and Openers.
Trads JB, Hüll K, Matsuura BS, Laprell L, Fehrentz T, Görldt N, Kozek KA, Weaver CD, Klöcker N, Barber DM, Trauner D.
Angew Chem Int Ed Engl. 2019 Oct 21;58(43):15421-15428. doi: 10.1002/anie.201905790. Epub 2019 Sep 12.
PMID: 31441199 Review.