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MSTPublications: January 2023

Posted by on Monday, January 30, 2023 in New Publications .

Prevalence, Risk Factors, and Sequelae of Asymptomatic Clostridioides difficile Colonization in Children with Cystic Fibrosis.
Reasoner SA, Fazili IF, Bernard R, Parnell JM, Sokolow AG, Thomsen KF, Edwards KM, Brown RF, Nicholson MR.
J Cyst Fibros. 2022 Dec 28:S1569-1993(22)01434-5. doi: 10.1016/j.jcf.2022.12.014. Online ahead of print.

Patients with CF (pwCF) have high antibiotic use and an altered intestinal microbiome, known risk factors for infection with Clostridioides difficile. However, in adults with CF, C. difficile infection (CDI) is uncommon and asymptomatic colonization with C. difficile occurs frequently, for reasons that remain unclear. We investigated the rate, risk factors, and sequelae of asymptomatic C. difficile colonization in children with CF (cwCF). We identified that 32% of cwCF were colonized with C. difficile without acute gastrointestinal symptoms. Higher BMI and exposure to specific antibiotic classes (cephalosporins, fluoroquinolones, and vancomycin) were significantly associated with C. difficile colonization. No children developed symptomatic CDI in 90-days following enrollment.

Benign Neurofibroma/Schwannoma Hybrid Peripheral Nerve Sheath Tumor of the Ulnar Nerve Harboring a Metastatic Papillary Thyroid Carcinoma Deposit: A Case Report of Tumor-to-Tumor Metastasis.
Colazo JM, Perez AN, Judice AD, Quirion J, Prieto-Granada CN, Holt GE.
Case Rep Pathol. 2022 Dec 14;2022:9038222. doi: 10.1155/2022/9038222. eCollection 2022.

A 74-year-old man with a medical history significant for papillary thyroid cancer (PTC) presented with a rapidly enlarging grape-sized mass in his right medial arm with paresthesia in the ulnar nerve distribution. Imaging was suspicious for a peripheral nerve sheath tumor (PNST), but an ultrasound-guided biopsy was equivocal. The mass was excised with final histopathology demonstrating a benign neurofibroma/schwannoma hybrid nerve sheath tumor (N/S HNST) harboring a metastatic PTC deposit, ultimately mimicking the rare glandular schwannoma subtype. Next-generation sequencing (NGS) of the lesion demonstrated somatic variants in BRAF and TERT (common in PTC) and NF2 (common in PNSTs). After excision, the patient’s nerve symptoms improved. A postsurgical PET/CT scan also showed progression in the lungs/mediastinum. Due to the metastatic nature of his PTC, he was treated with 14 mg of Lenvima (lenvatinib) daily, and his PET/CT surveillance was performed at more frequent intervals. Tumor-to-tumor metastasis (TTM) is a rare occurrence. To our knowledge, this is the first case reported on PTC metastasizing into a benign (hybrid) PNST, which mimicked glandular schwannoma. Symptomatology, imaging characteristics, NGS, and histopathological characteristics that can decipher between different benign PNST subtypes (schwannoma, neurofibroma, glandular, hybrid, etc.), malignant PNSTs (MPNSTs), and TTM are described.

Contraceptive exposure associates with urinary tract infection risk in a cohort of reproductive-age women: a case control study.
Lo C, Abraham A, Bejan CA, Reasoner SA, Davidson M, Lipworth L, Aronoff DM.
Eur J Contracept Reprod Health Care. 2022 Dec 20:1-6. doi: 10.1080/13625187.2022.2156278. Online ahead of print.

Mapping the impact of nonlinear gradient fields with noise on diffusion MRI.
Kanakaraj P, Cai LY, Rheault F, Yehe FC, Rogers BP, Schilling KG, Landman BA.
Magn Reson Imaging. 2023 Jan 9;98:124-131. doi: 10.1016/j.mri.2023.01.004. Online ahead of print.

Acly Deficiency Enhances Myelopoiesis through Acetyl Coenzyme A and Metabolic-Epigenetic Cross-Talk.
Greenwood DL, Ramsey HE, Nguyen PTT, Patterson AR, Voss K, Bader JE, Sugiura A, Bacigalupa ZA, Schaefer S, Ye X, Dahunsi DO, Madden MZ, Wellen KE, Savona MR, Ferrell PB, Rathmell JC.
Immunohorizons. 2022 Dec 1;6(12):837-850. doi: 10.4049/immunohorizons.2200086.

Community-guided measurement-based care for autistic youth and adults receiving psychotherapy: A conceptual overview and pilot implementation study of MBC-AUT.
Schwartzman JM, Williams ZJ, Paterson AV, Jacobs AX, Corbett BA.
Autism. 2023 Jan 11:13623613221143587. doi: 10.1177/13623613221143587. Online ahead of print.

Evaluating and Mitigating Bias in Machine Learning Models for Cardiovascular Disease Prediction.
Li F, Wu P, Ong HH, Peterson JF, Wei WQ, Zhao J.
J Biomed Inform. 2023 Jan 24:104294. doi: 10.1016/j.jbi.2023.104294. Online ahead of print.