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MSTPublications: May 2023

Posted by on Tuesday, May 30, 2023 in New Publications .

A Representativeness-informed Model for Research Record Selection from Electronic Medical Record Systems.
Borza VA, Clayton EW, Kantarcioglu M, Vorobeychik Y, Malin BA.
AMIA Annu Symp Proc. 2023 Apr 29;2022:259-268. eCollection 2022.

Scientific and clinical studies have a long history of bias in recruitment of underprivileged and minority populations. This underrepresentation leads to inaccurate, inapplicable, and non-generalizable results. Electronic medical record (EMR) systems, which now drive much research, often poorly represent these groups. We introduce a method for quantifying representativeness using information theoretic measures and an algorithmic approach to select a more representative record cohort than random selection when resource limitations preclude researchers from reviewing every record in the database. We apply this method to select cohorts of 2,000-20,000 records from a large (2M+ records) EMR database at the Vanderbilt University Medical Center and assess representativeness based on age, ethnicity, race, and gender. Compared to random selection – which will on average mirror the EMR database demographics – we find that a representativeness-informed approach can compose a cohort of records that is approximately 5.8 times more representative.


Exploratory validation of relationship functioning and non-pregnant partner behavior scales in pregnant people living with HIV in Mpumalanga Province, South Africa.
Sack DE, Seabi TM, Frisby MB, Diemer MA, Ndlovu GH, Wagner RG, Audet CM.
Glob Health Action. 2023 Dec 31;16(1):2210882. doi: 10.1080/16549716.2023.2210882.

Partner engagement in antenatal care can improve care for pregnant people living with HIV. However, concerns about engaging unsupportive non-pregnant partners warrant further study to avoid engaging partners who pressure their pregnant partner to refuse testing or treatment and/or perpetuate intimate partner violence. We adapted established relationship functioning and partner behaviour questionnaires among pregnant people living with HIV initiating antenatal care in rural South Africa. We identified 13 previously validated psychometric scales with 255 items that assess relationship functioning and partner behaviour, but, to our knowledge, had not been used in Southern Africa. After item translation and cognitive interviewing with 30 pregnant people, we recruited an additional 208 pregnant people living with HIV receiving antenatal care. We conducted an exploratory factor analysis with maximum-likelihood extraction and oblique promax rotation with the 58 items and 10 scales that remained after translation and cognitive interviewing. We used parallel analysis, scree plots, and the Kaiser criterion to guide factor retention and assessed internal factor consistency via Cronbach’s alpha. Of the 208 participants recruited, 197 (95%) answered each question and were included in the analysis. Exploratory factor analysis revealed 7 factors that assessed partner social support, sexual relationship power, emotional intimacy, threatened or enacted violence, sexual intimacy, violence in relationships, and partner engagement in pregnancy care via 37 items. Factor absolute Spearman correlations ranged from 0.012 to 0.518 and Cronbach’s alpha ranged from 0.84 to 0.92. This preliminary analysis will guide further scale development. Future developments will also include relevant clinical outcomes to assess the predictive validity of the resulting measures. These steps will further refine these questions into a succinct screening tool to assess relationship functioning and partner behaviour. This screening tool may eventually guide the selection of partner-based interventions during pregnancy to improve outcomes for pregnant people and their partners.


Macrocyclic Octapeptide Binding and Inferences on Protein Substrate Binding to Histone Deacetylase 6.
Watson PR, Gupta S, Hosseinzadeh P, Brown BP, Baker D, Christianson DW.
ACS Chem Biol. 2023 Apr 21;18(4):959-968. doi: 10.1021/acschembio.3c00113. Epub 2023 Apr 7.

SELENOP modifies sporadic colorectal carcinogenesis and WNT signaling activity through LRP5/6 interactions.
Pilat JM, Brown RE, Chen Z, Berle NJ, Othon AP, Washington M, Anant SA, Kurokawa S, Ng VH, Thompson JJ, Jacobse J, Goettel JA, Lee E, Choksi YA, Lau KS, Short SP, Williams CS.
J Clin Invest. 2023 May 11:e165988. doi: 10.1172/JCI165988. Online ahead of print.

Comparing voxel- and feature-wise harmonization of complex graph measures from multiple sites for structural brain network investigation of aging.
Newlin NR, Cai LY, Yao T, Archer D, Pechman KR, Schilling KG, Jefferson A, Resnick SM, Hohman TJ, Shafer AT, Landman BA.
Proc SPIE Int Soc Opt Eng. 2023 Feb;12464:124642B. doi: 10.1117/12.2653947. Epub 2023 Apr 3.

Deep Constrained Spherical Deconvolution for Robust Harmonization.
Yao T, Rheault F, Cai LY, Nath V, Asad Z, Newlin N, Cui C, Deng R, Ramadass K, Schilling K, Landman BA, Huo Y.
Proc SPIE Int Soc Opt Eng. 2023 Feb;12464:124640W. doi: 10.1117/12.2654398. Epub 2023 Apr 3.

Deep whole brain segmentation of 7T structural MRI.
Ramadass K, Yu X, Cai LY, Tang Y, Bao S, Kerley C, D’Archangel M, Barquero LA, Newton AT, Gauthier I, McGugin RW, Dawant BM, Cutting LE, Huo Y, Landman BA.
Proc SPIE Int Soc Opt Eng. 2023 Feb;12464:124642O. doi: 10.1117/12.2654108. Epub 2023 Apr 3.

Augmented-Reality Surgery to Guide Head and Neck Cancer Re-resection: A Feasibility and Accuracy Study.
Prasad K, Miller A, Sharif K, Colazo JM, Ye W, Necker F, Baik F, Lewis JS Jr, Rosenthal E, Wu JY, Topf MC.
Ann Surg Oncol. 2023 May 3. doi: 10.1245/s10434-023-13532-1. Online ahead of print.

Suppression of local inflammation via galectin-anchored indoleamine 2,3-dioxygenase.
Bracho-Sanchez E, Rocha FG, Bedingfield SK, Partain BD, Macias SL, Brusko MA, Colazo JM, Fettis MM, Farhadi SA, Helm EY, Koenders K, Kwiatkowski AJ, Restuccia A, Morales BS, Wanchoo A, Avram D, Allen KD, Duvall CL, Wallet SM, Hudalla GA, Keselowsky BG.
Nat Biomed Eng. 2023 May 1. doi: 10.1038/s41551-023-01025-1. Online ahead of print.

STING-activating nanoparticles normalize the vascular-immune interface to potentiate cancer immunotherapy.
Wang-Bishop L, Kimmel BR, Ngwa VM, Madden MZ, Baljon JJ, Florian DC, Hanna A, Pastora LE, Sheehy TL, Kwiatkowski AJ, Wehbe M, Wen X, Becker KW, Garland KM, Schulman JA, Shae D, Edwards D, Wolf MM, Delapp R, Christov PP, Beckermann KE, Balko JM, Rathmell WK, Rathmell JC, Chen J, Wilson JT.
Sci Immunol. 2023 May 12;8(83):eadd1153. doi: 10.1126/sciimmunol.add1153. Epub 2023 May 5.

Implementation of required sedation assessment in nursing workflow to address naloxone utilization.
Hardison E, Bloomer A, Wally MK, McArthur E, Hsu JR, Bear S, Jarrett S, Roomian T, Sullivan DM, Wold K, Yu Z, Odum S, Seymour RB.
J Opioid Manag. 2023 May-Jun;19(3):247-255. doi: 10.5055/jom.2023.0780.

The Role of Mobile Genetic Elements in Virulence Factor Carriage from Symptomatic and Asymptomatic Cases of Escherichia coli Bacteriuria.
Morales G, Abelson B, Reasoner S, Miller J, Earl AM, Hadjifrangiskou M, Schmitz J.
Microbiol Spectr. 2023 May 17:e0471022. doi: 10.1128/spectrum.04710-22. Online ahead of print.

Exploring Risk Factors in Suicidal Ideation and Attempt Concept Cooccurrence Networks.
Krause KJ, Shelley J, Becker A, Walsh C.
AMIA Annu Symp Proc. 2023 Apr 29;2022:644-652. eCollection 2022.

A practical approach to curate clonal hematopoiesis of indeterminate potential in human genetic data sets.
Vlasschaert C, Mack T, Heimlich JB, Niroula A, Uddin MM, Weinstock J, Sharber B, Silver AJ, Xu Y, Savona M, Gibson C, Lanktree MB, Rauh MJ, Ebert BL, Natarajan P, Jaiswal S, Bick AG.
Blood. 2023 May 4;141(18):2214-2223. doi: 10.1182/blood.2022018825.

Inflammation Resolution in the Cardiovascular System: Arterial Hypertension, Atherosclerosis, and Ischemic Heart Disease.
Gonzalez AL, Dungan MM, Smart CD, Madhur MS, Doran AC.
Antioxid Redox Signal. 2023 Apr 26. doi: 10.1089/ars.2023.0284. Online ahead of print.

Forwarding the Science of Sensory Features in Autism and Related Conditions.
Schaaf RC, Puts NA, Williams ZJ, Woynaroski T.
J Autism Dev Disord. 2023 May 4. doi: 10.1007/s10803-023-05959-y. Online ahead of print.

The human α cell in health and disease.
Pettway YD, Saunders DC, Brissova M.
J Endocrinol. 2023 Apr 1:JOE-22-0298. doi: 10.1530/JOE-22-0298. Online ahead of print.

Die Kämpfe únd schláchten-the struggles and battles of innate-like effector T lymphocytes with microbes.
Joyce S, Okoye GD, Driver JP.
Front Immunol. 2023 Apr 24;14:1117825. doi: 10.3389/fimmu.2023.1117825. eCollection 2023.

Anti-ableist language is fully compatible with high-quality autism research: Response to Singer et al. (2023).
Natri HM, Abubakare O, Asasumasu K, Basargekar A, Beaud F, Botha M, Bottema-Beutel K, Brea MR, Brown LXZ, Burr DA, Cobbaert L, Dabbs C, Denome D, Rosa SDR, Doherty M, Edwards B, Edwards C, Liszk SE, Elise F, Fletcher-Watson S, Flower RL, Fuller S, Gassner D, Onaiwu MG, Good J, Grant A, Haddix VL, Heraty S, Hundt A, Kapp SK, Keates N, Kulshan T, Lampi AJ, Latimer O, Leadbitter K, Tidd JL, Manalili M, Martin M, Millichamp A, Morton H, Nair V, Pavlopoulou G, Pearson A, Pellicano L, Porter H, Poulsen R, Robertson ZS, Rodriguez K, Roux A, Russell M, Ryan J, Sasson N, Grier HS, Somerville M, Sorensen C, Stockwell KM, Szymanski T, Thompson-Hodgetts S, van Driel M, VanUitert V, Waldock K, Walker N, Watts C, Williams Z, Woods R, Yu B, Zadow M, Zimmerman J, Zisk AH.
Autism Res. 2023 Apr;16(4):673-676. doi: 10.1002/aur.2928.