MSTPublications: December 2017

December 14, 2017
Posted in New Publications

Congratulations to all of our MSTP students on their successful publications! Take a look at the great work our students are doing.

First Author Original Research:

IL-33 promotes the egress of group 2 innate lymphoid cells from the bone marrow.
Stier MT, Zhang J, Goleniewska K, Cephus JY, Rusznak M, Wu L, Van Kaer L, Zhou B, Newcomb DC, Peebles RS Jr.
J Exp Med. 2017 Dec 8. pii: jem.20170449. doi: 10.1084/jem.20170449. [Epub ahead of print]

Group 2 innate lymphoid cells (ILC2s) are effector cells within the mucosa and key participants in type 2 immune responses in the context of allergic inflammation and infection. ILC2s develop in the bone marrow from common lymphoid progenitor cells, but little is known about how ILC2s egress from the bone marrow for hematogenous trafficking. In this study, we identified a critical role for IL-33, a hallmark peripheral ILC2-activating cytokine, in promoting the egress of ILC2 lineage cells from the bone marrow. Mice lacking IL-33 signaling had normal development of ILC2s but retained significantly more ILC2 progenitors in the bone marrow via augmented expression of CXCR4. Intravenous injection of IL-33 or pulmonary fungal allergen challenge mobilized ILC2 progenitors to exit the bone marrow. Finally, IL-33 enhanced ILC2 trafficking to the lungs in a parabiosis mouse model of tissue disruption and repopulation. Collectively, these data demonstrate that IL-33 plays a critical role in promoting ILC2 egress from the bone marrow. (By Matt Stier, M3)


Co-authorships, Clinical Studies, and Reviews:

Structural basis of respiratory syncytial virus subtype-dependent neutralization by an antibody targeting the fusion glycoprotein.
Tian D, Battles MB, Moin SM, Chen M, Modjarrad K, Kumar A, Kanekiyo M, Graepel KW, Taher NM, Hotard AL, Moore ML, Zhao M, Zheng ZZ, Xia N]S, McLellan JS, Graham BS.
Nat Commun. 2017 Nov 30;8(1):1877. doi: 10.1038/s41467-017-01858-w.

Invasive Insular Sampling in Pediatric Epilepsy: A Single-Institution Experience.
Tomycz LD, Hale AT, Haider AS, Clarke DF, Lee MR.
Oper Neurosurg (Hagerstown). 2017 Dec 13. doi: 10.1093/ons/opx253. [Epub ahead of print]

Stereotactic EEG via multiple single-path omnidirectional trajectories within a single platform: institutional experience with a novel technique.
Dewan MC, Shults R,
Hale AT, Sukul V, Englot DJ, Konrad P, Yu H, Neimat JS, Rodriguez W, Dawant BM, Pallavaram S, Naftel RP.
J Neurosurg. 2017 Dec 15:1-9. doi: 10.3171/2017.6.JNS17881. [Epub ahead of print]

Role of Estrogens in the Regulation of Liver Lipid Metabolism.
Palmisano BT, Zhu L, Stafford JM.
Adv Exp Med Biol. 2017;1043:227-256. doi: 10.1007/978-3-319-70178-3_12.

Hypertrophic cardiomyopathy-linked mutation in troponin T causes myofibrillar disarray and pro-arrhythmic action potential changes in human iPSC cardiomyocytes.
Wang L, Kim K,
Parikh S, Cadar AG, Bersell KR, He H, Pinto JR, Kryshtal DO, Knollmann BC.
J Mol Cell Cardiol. 2017 Dec 4. pii: S0022-2828(17)30358-9. doi: 10.1016/j.yjmcc.2017.12.002. [Epub ahead of print]

The receptor tyrosine kinase EphA2 promotes glutamine metabolism in tumors by activating the transcriptional coactivators YAP and TAZ.
Edwards DN, Ngwa VM, Wang S, Shiuan E, Brantley-Sieders DM, Kim LC, Reynolds AB, Chen J.
Sci Signal. 2017 Dec 5;10(508). pii: eaan4667. doi: 10.1126/scisignal.aan4667.

Innate lymphoid cells and allergic disease.
Stier MT, Peebles RS Jr.
Ann Allergy Asthma Immunol. 2017 Dec;119(6):480-488. doi: 10.1016/j.anai.2017.08.290. Review.