In its attempts to understand learning and memory, modern neuroscience research uses a variety of techniques. New tools such as optogenetics, chemogenetics, CLARITY, TRIO, etc., give unprecedented insight into the circuits, cell types, and physiologic changes governing behavior. Implicit in this work is the idea that alterations in the strength of connections between neurons underlie learning and memory. This idea was developed in part by Dr. Eric Kandel through his work with the sea slug, Aplysia, which won him the 2000 Nobel Prize in Physiology or Medicine. I was fortunate to hear Dr. Kandel speak three times over the course of a month: at lecture during the APSA/AAP/ASCI conference in Chicago, the Flexner Discovery Lecture at Vanderbilt, and at a brunch gathering.