Hdac2 is a gene that suppresses learning and memory. Repression of Hdac2 has been shown to improve memory formation, and Hdac2 inhibitors have been studied for treatment of autism spectrum disorders and Alzheimer’s disease. I am investigating mechanisms that regulate the transcription of this gene using molecular biology and next generation sequencing. I am also using an in vitro system to study how Hdac2 repression affects the expression of other genes during neuronal depolarization.
Postdoctoral Scholar, Sweatt Lab