Research Cores and Shared Resources

Biomedical research at VUMC is supported by designated institutional cores and shared resources. These facilities offer cutting edge scientific services, enabling access to high-end equipment, advanced techniques and specialized expertise for all Vanderbilt investigators.

Detailed policy and other support information for core facilities can be found in the Core Administration & Policies section.


Vanderbilt University Medical Center Institutional Core Facilities or Research Centers (Click on a link below for more information)

A complete listing of all cores, including departmental and limited service cores, can be found in the Research Cores and Shared Resources section.

Offers computing resources flexible enough to enable High Performance Computing applications in a wide variety of research and education areas. Researchers from thirty campus departments and four schools use ACCRE for their computation needs.  

Managing Director: Carrie Lee Kennedy
E-Mail: carielee.kennedy@Vanderbilt.Edu
Phone: (615) 343-2244
Website: http://www.accre.vanderbilt.edu/

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Provides, enhances, and/or facilitates statistical collaborations involving the design, conduct, analysis or publication of biomedical research at the university. The BCC is comprised of biostatisticians and computer systems analysts from the Department of Biostatistics who are available to work with faculty on a variety of projects. They offer a wide range of highly trained experts with unique expertise for almost any collaboration. The BCC has considerable expertise in the design, conduct, and analysis of large scale clinical trials and research design for basic biomedical research. Varying levels of expertise are also available for consultation, from bachelor’s and master’s level trained biostatisticians and computer systems analysts to full professors.
Biostatistics Collaboration Center Manager: Seth Martin
E-Mail: Seth.Martin@vanderbilt.edu
Website: http://biostat.mc.vanderbilt.edu/wiki/Main/Clinics

Provides enabling resource for exploration of the relationships among genetic variation, disease susceptibility, and variable drug responses, and represents a key first step in moving the emerging sciences of genomics and pharmacogenomics from research tools to clinical practice.  A major goal of the resource is to generate datasets that incorporate de-identified information derived from medical records and genotype information to identify factors that affect disease susceptibility, disease progression, and/or drug response.

Manager: Erica Bowton
E-Mail: erica.bowton@vanderbilt.edu
Phone: (615) 322-1975

Website: https://starbrite.vanderbilt.edu/biovu/ (VUnet password required.)

 

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Supports the full range of modern microscopy and digital imaging capabilities in order to enable and accelerate research that would otherwise be reduced in quantity and quality. Currently over 200 research groups use the facilities and services of the Resource, which maintains an active development program to keep the instrumentation and systems current, functional, accessible, and easy to use.  CISR currently provides facilities for both optical and electron microscopy; there are six confocal microscopes, one line-scanning microscope, two 2-photon-excitation microscopes, and four advanced wide-field microscopes as well as a Phillips CM-12 120keV Transmission Electron microscope system.

The laboratory is fully equipped to carry out numerous aspects of "routine" as well as specialized electron microscopy. Included in the specialized services available through the resource are: 1) preparative techniques, such as embedding and sectioning, critical point drying, high-resolution low angle and rotary shadowing, and cryo-EM; 2) research techniques, such as immuno- and enzyme-cytochemistry, autoradiography, and whole-mount microscopy; and 3) analytical techniques, such as on- and off-line microcomputer based systems for image processing, pattern analysis, and 3-D reconstruction.

Director: Sam Wells
E-Mail: sam.wells@vanderbilt.edu

Co-Director – Electron Microscopy: Jay Jerome E-Mail: jay.jerome@vanderbilt.edu

Website: http://cisrweb.mc.vanderbilt.edu/CISR/index.php

Faculty Advisory Committee Memebers (2012-2013):
Elisabeth Dykens (Kennedy Center)
Jim Goldenring (Surgical Sciences)
Scott Hiebert (Cancer Center)
David Kosson (Civil & Environmental Engineering)
Mark Magnuson (Stem Cell Biology)
Richard Peek (Digestive Disease Research Center) Al Powers (Diabetes Center)
Jeffrey Schall (Vision Research Center)
David Wasserman (Mouse Metabolic Phenotyping Center)
Chris Wright (Program in Developmental Biology)


 

Provides  consultative services for VICC investigators in the statistical design, conduct, and analysis of studies; collaborates in funded research efforts initiated by VICC laboratory and clinical investigators, by providing statistical expertise in study design, power and sample size analysis; data analysis; interpretation of results; and writing of manuscripts; provides relational database design, data tracking, forms, queries, and reports for investigator-initiated clinical trial databases or laboratory study databases; and develops and evaluate statistical methods for experimental design and data analysis.

Contact Lynne Berry for more information. 
E-Mail: lynne.d.berry@Vanderbilt.Edu
Website: http://www.vicc.org/biostatistics/about.php

The purpose of the Vanderbilt Clinical Research Center is to provide the resources needed by clinical and translational investigators to carry out their research in an environment optimized for safety, comfort and convenience of the patient or volunteer, with the facilities and expertise to provide the most advantageous milieu in which to address the investigator's experimental requirements. This includes outpatient space, inpatient beds, laboratories, equipment and supplies for clinical research by the faculty of Vanderbilt University, Meharry Medical College, and their collaborating investigators. The use of the center is justified on the basis of the quality and significance of the research and the special need for the Center's facilities.

In the process of achieving its primary objective, the Clinical Research Center can also serve as a resource for teaching medical, graduate, and other multidisciplinary students, a site for research on the methodology of patient care systems, and an unique environment for the apprenticeship of young clinical investigators. The center is a component of the Vanderbilt Institute of Clinical and Translational Research (VICTR) organized under a Clinical and Translational Award (CTSA) made in 2007 by the National Center for Research Resources and the National Institute of Health.

Program Manager: Jennifer Adams
E-Mail: jennifer.s.adams@vanderbilt.edu
Phone: (615) 343-3655
Website: http://www.mc.vanderbilt.edu/crc/

 

The Digital Histology Shared Resource provides large-scale digital archiving and quantitative analysis of histological, immunocytochemical and immunofluorescence staining for tissue sections and tissue microarrays. The Ariol SL-50 automated scanning microscope and the Leica SCN400 Slide Scanner deliver solutions for high-resolution imaging in both bright field and fluorescence. Both instruments have high-capacity robotic autoloading (50 slides for the Ariol SL-50 and 384 slides for the Leica SCN400) making them ideal for large slide cohorts and tissue microarrays. The Leica SCN400 scanner can image normal size as well as large format slides and whole mounts.  The associated software packages provide complex algorithms for unbiased, automated image analysis and quantitation of immunostaining in both bright field and fluorescence. In addition, these systems can be utilized as a permanent high-resolution solution for those who need archiving of histological material. The DHSR hosts a convenient, web-based digital slide-viewing environment (Digital Image Hub) for the rapid retrieval, review and annotation of scanned material. This easy to use digital slide box allows researchers to share images among colleagues, both at Vanderbilt and at other institutions, from any web browser while remaining in a digitally secure environment. Built-in conferencing features allow investigators to coordinate multi-site discussions of histological samples.

The DHSR also supports shared usage of a Applied Precision/GE Deltavision Deconvolution Fluorescence microscope equipped with a Weatherstation for extended live cell imaging.  The DHSR also houses an Optronix Digital Colony Counter for automated counting and size quantitation of cell colonies grown in multiple culture formats.

Scientific Director: James R. Goldenring, M.D., Ph.D.
Managing Director: Joseph Roland, Ph.D.
E-Mail: joseph.t.roland@vanderbilt.edu
Website: http://www.mc.vanderbilt.edu/root/vumc.php?site=dhsr

A new disk storage device called DORS is now mounted on ACCRE via collaboration between the Center for Structural Biology, the VUMC Office of Research, VUIT and ACCRE.

Director: Jarrod Smith, Ph.D.
E-Mail: jarrod.smith@Vanderbilt.Edu
Phone: (615) 554-5681 
Website: http://www.accre.vanderbilt.edu/?page_id=1729

 

 

The Division of Animal Care (DAC) is the service core of the Office of Research that provides procurement, husbandry, and healthcare for experimental animals, as well as scientific/technical support for VU researchers.

Our mission is to provide humane animal care that meets the highest national standards supporting knowledge and discovery through research. To that end, the DAC endeavors to provide excellent animal care and customer service in support of Vanderbilt’s research and teaching programs. 

Office hours are 7:30am-4:30pm Monday-Friday.

For weekend, holiday and after-hours emergencies, contact the DAC by calling the numbers posted near the phones located in each facility or dialing 615.322.2231 and listening to the message to identify the appropriate individual to call.

E-Mail: DACBilling@vanderbilt.edu
Website: https://www4.vanderbilt.edu/acup/ - (VUnet password required. )

Provides flow cytometry servides to faculty, staff, and students in the VUMC and to other investigators on a fee-for-service basis.  The staff Maintains all instruments and provides the following services: Data acquisition, both by facility staff and qualified users, soring, instruction in performing data analysis, instruction on instrument user (analytical machine), consultation on experimental design, sample handling, and staining protocols, eduction on basic principles of flow cytometry through seminars, lab meeting sand course work.

Scientific Director: James Crowe, MD
Managing Director: Kevin Weller
E-Mail: kevin.p.weller@vanderbilt.edu
Website: http://www.mc.vanderbilt.edu/root/vumc.php?site=flowcytometry
Faculty Advisory Committee Members:
Mark Boothby (Pathology, Microbiology & Immunology)
Alyssa Hasty (Molecular Physiology & Biophysics)
Scott Hiebert (Cancer Center)
David Miller (Cell and Developmental Biology) Richard Peek (Digestive Disease Research Center)
Eric Sebzda (Pathology, Microbiology & Immunology)
Michelle Southard-Smith (Genetic Medicine)
 

Advisory Committee Meetings:
February 7, 2013
September 2, 2010

HEALTH SERVICES RESEARCH CORES

Database Analysis Core 
Offers education, consultation, and programming support on capabilities, access, and appropriate use of large publicly available health-related datasets for the purposes of developing hypotheses for health research, guiding policy choices, or documenting community health concerns. Contact: amy.j.graves@vanderbilt.edu.

Human Factors and Systems Safety Core 
Provides training and assistance in observing and analyzing human factors involved in both individual clinical tasks and complex health systems in order to improve patient safety and provider and system efficiency in health care delivery. Contact:christine.goldsberry@vanderbilt.edu

Qualitative Research Core 
Offers consultative services, equipment, and facilitation to support investigators planning to conduct qualitative studies, with a particular focus on use of structured and semi-structured interviews, web-based collection of qualitative data, direct observation of behavior, and focus groups. Contact: clare.sullivan@vanderbilt.edu.

CTSA SUPPORTED CORES

Meharry-Vanderbilt Community Engaged Research Core (CERC) 
Offers consultation, infrastructure and support services to facilitate community engagement in clinical and translational research. Services include consultations with faculty experienced in community engaged methods of research, Community Review Boards, training on community engagement strategies, and connections to potential community partners. CERC is also working to develop a middle Tennessee practice-based research network. Contact: yvonne.joosten@vanderbilt.edu.

Effective Health Communication Core 
Provides consultation on aspects of research study design, informed consent, patient recruitment, measurement, data collection, quantitative and qualitative analysis, and manuscript preparation related to health literacy, numeracy, cross-cultural communication and mobile device or internet-based communication. Contact: kathryn.m.goggins@Vanderbilt.Edu

Assists investigators in the measurement of amino acid profiles and hormones in biologic fluids as related to diabetes and endocrine and metabolic research. The core provides space, equipment, and personnel for sample analysis and method development.

Manager: Dale Edgerton
E-Mail: dale.edgerton@vanderbilt.edu
Phone: (615) 936-1624
Website: http://hormone.mc.vanderbilt.edu/

The Immunology Core provides a wide-range of support and assays to assist investigators in their research with a primary interest in assessing immune responses during clinical trials. We strive to assist investigators with sample processing, storage, shipping, documentation, assay design, assay development and evaluation of immune responses.  Our dedicated staff can provide consultation to investigators on the types of immune assays to choose for clinical trial monitoring and data interpretation.

Managing Director: Michael Rock, Ph.D.
E-Mail: michael.rock@vanderbilt.edu
Phone (Office): 615-322-4494
Phone (Lab): 615-322-3156
Website: http://www.mc.vanderbilt.edu/root/vumc.php?site=immunocore

The Investigational Drug Service (IDS)  is a team of specially trained pharmacists and certified pharmacy technicians within the VUMC Department of Pharmaceutical Services. The IDS team is dedicated to helping investigators accomplish research goals while maintaining compliance with all applicable standards and regulations. Study protocol dispensing can be accommodated for inpatient and outpatient studies on the main campus and at clinic sites such as One Hundred Oaks.

Program Director: Rick Malone
E-Mail: richard.e.malone@vanderbilt.edu
Phone: (615) 343-5146, (615) 500-2981
Website: http://www.mc.vanderbilt.edu/root/vumc.php?site=pharmacy&doc=7014

Provides instrumentation for structural analysis of biological molecules and qualitative and quantitative assays of chemotherapeutic agents and metabolites in physiological fluids. The instrumentation facilities consist of a variety of mass spectrometric and high-pressure liquid chromatographic systems.

Learn more about MSRC's core capabilities, educational opportunities, and current research: Watch the video.

Mass Spectrometry Core 
Provides instrumentation for structural analysis of biological molecules and qualitative and quantitative assays of chemotherapeutic agents and metabolites in physiological fluids. The instrumentation facilities consist of a variety of mass spectrometric and high-pressure liquid chromatographic systems.
Director: Kevin Schey
Assistant Director: Wade Calcutt
E-Mail: wade.calcutt@Vanderbilt.Edu
Website: http://www.mc.vanderbilt.edu/root/vumc.php?site=msrc/mass_spectrometry_core_lab

Faculty Advisory Committee Members (2012-2013):
Michael Aschner (Molecular Toxicology)
Alan Brash (Clinical Pharmacology)
Roger Colbran (Molecular Physiology & Biophysics)
Sean Davis (Clinical Pharmacology)
Fred Guengerich (Biochemistry)
Scott Hiebert (VICC)
Larry Marnett (VICB)
Claus Schneider (Clinical Pharmacology)
Eric Skaar (Pathology, Microbiology & Immunology)

Advisory Committee Meetings:
April 11, 2013
August 9, 2010


Proteomics Core

Provides state-of-the-art instrumentation and expertise in analytical proteomics, proteome profiling, and imaging to Vanderbilt researchers.  Instrumentation is available for protein and peptide separations by 2D-gel electrophoresis and multidimensional high performance liquid chromatography (LC).

Proteins and peptides of interest are processed and subjected to mass spectral (MS) analysis, and protein identifications are made based on a comparison of MS data with sequence information from genomic, protein, and EST databases.  Proteome profiling and imaging in frozen tissue sections are done by matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) MS.  Proteomics Laboratory staff provide consultation on experimental design and sample preparation.

Director: Kevin Schey

Co-Associate Director: Hayes McDonald
E-Mail: hayes.mcdonald@vanderbilt.edu
Website: http://www.mc.vanderbilt.edu/root/vumc.php?site=msrc/proteomics_core

Tissue/Serum Proteomics Core Director: Richard Caprioli
Website: http://www.mc.vanderbilt.edu/root/vumc.php?site=msrc/tissuecore

​Faculty Advisory Committee Members (2012-2013):
Roger Colbran (Molecular Physiology & Biophysics)
David Cortez (Biochemistry)
Timothy Cover (Infectious Disease)
Scott Hiebert (Cancer Center)
Andrew Link (Pathology, Microbiology & Immunology)
Larry Marnett (Institute for Chemical Biology)
Richard Peek (Digestive Disease Research Center )

Advisory Committee Meetings:
April 2, 2013
August 26, 2010


Tissue/Serum Proteomics Core

Offers a variety of services in order to determine the proteomic profiles of tissue, serum, and other biological fluids using MALDI mass spectrometry.  Investigators work closely with Core personnel in order to design the experiment that will best answer the scientific questions being posed.  The typical study involves examining protein changes between two experimental groups; e.g., control vs. diseased or treated vs. nontreated. The services offered by the Tissue/Serum Proteomics Core include tissue profiling, tissue imaging, 1D and 2D robotic biofluid fractionation and protein profiling, and multidimensional LC-MS/MS “shotgun” proteomics analysis of biofluids and tissue homogenates.  In addition, various biocomputational services are offered in conjunction with data acquisition, including biostatistical comparisons of sample groups and image processing.


Director: Richard Caprioli
Website: http://www.mc.vanderbilt.edu/root/vumc.php?site=msrc/tissuecore

This resource provides custom DNA and RNA synthesis as well as custom cell culture media at a fraction of the cost of commercial sources. The supply arm of this resource stocks freshly prepared bacteria growth plates with or without antibiotics, transformation competent bacteria, and commercial kits and reagents for molecular biology research.  On-line ordering is available and there is free delivery to the lab.

The Bioanalytics Facility houses state-of–the-art instrumentation for imaging and quantitation of fluorescent, radioactive, luminescent, and chemiluminescent signals from gels, membranes, or multiple well plates. Gels and membranes stained with visible dyes or ethidium bromide can also be analyzed. Digitized images can be saved to transportable storage for further analysis in the lab or prints can be made on site. This facility also has four "real-time" PCR instruments available on a sign-out basis.

Manager: Kris Ellis 2-7238
E-Mail: kris.ellis@Vanderbilt.Edu
Website:http://thecore.vanderbilt.edu/

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The Mouse Metabolic Phenotyping Center provides investigators wishing to address hypotheses related to diabetes and metabolism with a range of animal model systems. Assistance with mouse experimentation falls under the auspices of the Mouse Metabolic Phenotyping Center, which branched off from this core in 2001. Expertise of core personnel reflects the need to assist in both small and large animal experiments.
 
Services provided are surgical, experimental, with limited analytical capacity (blood glucose, serology).  Emphasis is on procedures needed to study conscious, unrestrained animals.  Equipment available to investigators includes infusion pumps, blood flow meters, blood pressure monitors, gas analyzers, centrifuges, and glucose analyzers. The Animal Resources Core is experienced in developing new procedures and animal models to accommodate evolving research needs. Many of the procedures conducted in this core are novel. For this reason, training of investigators is an important responsibility of the Animal Resources Core.

Director: David Wasserman
E-mail: mmpc@vanderbilt.edu
Website: https://labnodes.vanderbilt.edu/mmpc

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Offers services for neurochemical profiling of brain, peripheral tissues and body fluids. The core provides analytical services for the quantitation of multiple biogenic amine neurotransmitters (e.g. dopamine, norepinephrine, serotonin, acetylcholine), biogenic amine metabolites, amino acids and amino acid neurotransmitters (e.g. glutamate, GABA). Investigators provide primary tissue samples or extracts stabilized for analysis.

Core Director: Ginger Milne
E-Mail: ginger.milne@vanderbilt.edu
Phone: (615) 936-5611

Website: http://www.mc.vanderbilt.edu/root/vumc.php?site=neurosci&doc=697

This facility provides infrastructure and guidance to support the assessment of behavior in genetically altered mice. Automated, computer-controlled instrumentation provides for assessment of motor and cognitive behavior as well as drug responses. MNL core personnel consult with investigators on experimental design and train core users in animal handling, data acquisition, and statistical analysis.  Core personnel may also assist with writing methods and results sections for manuscripts or grants.
 



Murine Neurobehavioral Laboratory

This facility provides infrastructure and guidance to support the assessment of behavior in genetically altered mice. Automated, computer-controlled instrumentation provides for assessment of motor and cognitive behavior as well as drug responses. MNL core personnel consult with investigators on experimental design and train core users in animal handling, data acquisition, and statistical analysis.  Core personnel may also assist with writing methods and results sections for manuscripts or grants.


Manager: John Allison
E-Mail: john.d.allison@vanderbilt.edu
Phone: (615) 322-0794
Website: http://www.vandymouse.org/
 
Provides equipment, training and consulting for Vanderbilt personnel who are interested in studying rat models of both neurological and psychiatric disorders. Examples of assays available for research in rats include models of anxiety, depression, drug abuse, learning and memory, cognition, attention, social interaction, pain, motor activity and coordination. Investigators can employ the latest technology in video capture and software-based analysis of behavior.
 



Rat Neurobehavioral Laboratory

Provides equipment, training and consulting for Vanderbilt personnel who are interested in studying rat models of both neurological and psychiatric disorders. Examples of assays available for research in rats include models of anxiety, depression, drug abuse, learning and memory, cognition, attention, social interaction, pain, motor activity and coordination. Investigators can employ the latest technology in video capture and software-based analysis of behavior.

Website:https://medschool.vanderbilt.edu/rat-core/

The Vanderbilt Sleep Research Core offers two hard-wired sleep systems with synchronized video-polysomnography and 21 channels of EEG, with dedicated registered sleep technologists. A sleep core/sleep reading center manager and the core director (Dr. Beth Malow) assist investigators with protocol development. It offers polysomnography, titrations with continuous positive airway pressure, multiple sleep latency testing, and wrist actigraphy (wireless devices that measure sleep-wake patterns non-intrusively based on accelerometers that measure activity vs. rest). The core provides for centralized scoring of polysomnography and actigraphy data for multicenter trials.  In addition to the scoring component, emphasis is placed on the quality of the sleep recordings at the individual sites with close communication among the individual site technologists and the sleep core manager.

Scientific Director: Beth Malow
E-Mail: beth.malow@vanderbilt.edu
Manager: Melissa Francis 
E-Mail: melissa.francis@Vanderbilt.Edu

Website: http://www.mc.vanderbilt.edu/root/vumc.php?site=sleepcore

The Translational Pathology Shared Resource will advance biomedical research and personalized medicine by providing Vanderbilt Investigators:

  • Access to consented and de-identified human tissue specimens
  • Comprehensive, state of the art diagnostic, necropsy and comparative pathology services for animal model systems with specific expertise and focus on mouse models
  • Research histology including advanced techniques, immunohistochemistry, laser capture micro-dissection and tissue micro-array preparation
  • Access to experts in veterinary and human pathology

Website: http://www.mc.vanderbilt.edu/root/vumc.php?site=tpsr

Associate Director: Kelli Boyd
E-Mail: kelli.l.boyd@vanderbilt.edu
Phone: (615) 322-3596

TPSR Contact: Sherry Smith
E-Mail: sherry.smith@vanderbilt.edu
Phone: (615) 322-3667

 

The Vanderbilt Center for Stem Cell Biology aims to understand the biology of stem cells and the mechanisms for directing their differentiation to specific cell fates. It is home to the Beta Cell Biology Consortium, a group of scientists dedicated to learning how to make pancreatic beta, which are destroyed in Type 1 diabetes, from embryonic stem cells.

Director: Mark Magnuson

Transgenic Mouse/ESC Shared Resource
Scientific Co-Directors: Mark Magnuson and Doug Mortlock
E-Mail:mark.magnuson@Vanderbilt.Edu – douglas.p.mortlock@Vanderbilt.Edu

Managing Co-Director: Jennifer Skelton
E-Mail:Jennifer.Skelton@Vanderbilt.Edu
Website:http://labnodes.vanderbilt.edu/tmescsr

Vanderbilt’s Center for Structural Biology is dedicated to enabling and proliferating research with the goal of determining the 3D structure of biological macromolecules at or near atomic resolution. Participating researchers have access to protein expression and purification, crystallography, NMR, and molecular graphics core facilities to aid in the determination of biomacromolecular structure.
 
Director: Walter Chazin
E-Mail: walter.chazin@Vanderbilt.Edu

Biomolecular NMR Facility
Scientific Director: Chuck Sanders
E-Mail: chuck.sanders@vanderbilt.edu

Director of Operations: Markus Voehler
E-Mail: m.voehler@Vanderbilt.Edu
Website: http://structbio.vanderbilt.edu/nmr/

Biomolecular Crystallography Facility
Director of Operations: Joel Harp
E-Mail: joel.harp@Vanderbilt.Edu
Website: http://structbio.vanderbilt.edu/xray/

Biophysical Instrumentation Core Facility
Director of Operations: Walter Chazin
E-Mail: walter.chazin@Vanderbilt.Edu
Website: http://structbio.vanderbilt.edu/wetlab/instrumentation.php
 

VICB research spans a broad range of interests and is characterized by interdisciplinary and cross-disciplinary approaches. Many VICB members have affiliations with other key institutes and centers at Vanderbilt, including the Vanderbilt Ingram Cancer Center (VICC), the Institute of Imaging Science (VUIIS), the Center for Structural Biology (CSB), the Mass Spectrometry Research Center (MSRC) and the Institute of Nanoscale Science and Engineering (VINSE). All investigators have access to VICB core facilities that provide chemical synthesis, high throughput screening, antibody production, and small molecule NMR services.

Director: Larry Marnett
E-Mail: larry.marnett@Vanderbilt.Edu

VICB Chemical Synthesis Core
Scientific Director: Gary Sulikowski
E-Mail: gary.a.sulikowski@vanderbilt.Edu
Assistant Director:  Kwangho Kim
E-Mail: kwangho.kim@vanderbilt.edu
Phone: (615) 322-7324
Website: http://www.vanderbilt.edu/syncore/

VICB High-Throughput Screening Facility
Scientific Director: David Weaver
Director: Paige Vinson
E-Mail: paige.n.vinson@vanderbilt.edu
Phone: (615) 322-0342
Website: http://www.vanderbilt.edu/hts/

Vanderbilt Antibody & Protein Resource
Director: Rob Carnahan
E-Mail: vmac@vanderbilt.edu
Phone: (615) 322-5623
Website: https://www4.vanderbilt.edu/vapr/home

Vanderbilt Small Molecule NMR Facility
Director: Don Stec
E-Mail: donald.f.stec@vanderbilt.edu
Phone: (615) 322-6704
Website: https://medschool.vanderbilt.edu/annmr

VANTAGE is a genomics core laboratory consolidation initiated by an $8.6 million ARRA funded NIH grant award to Vanderbilt University Medical Center, with an overall goal of creating a new collaborative  [VANTAGE] shared resource that accelerates discovery in genome sciences and personalized medicine, providing state-of-the art research shared resource facilities and technology.


The NIH grant provided funds for complete modernization of 12,505 Net Square Feet of aging laboratory space in Medical Center North, and for new cutting edge scientific equipment now utilized by the core labs located in the newly renovated space. Renovation was completed in May 2012, and the core labs (see below) are now in full service mode in their new laboratories.


VANTAGE is a one-stop genomics research resource, including: Illumina genotyping, DNA extraction and banking, Affymetrix–based genotyping and expression microarrays, Sanger sequencing and Next Generation Sequencing (NGS) among many other specialized services. These activities are now part of an overall structure that takes full advantage of their new physical co-location together with the Flow Cytometry Shared Resource in VANTAGE.


Center for Technology Transfer and Commercialization toured VANTAGE as part of DNA Day celebration: Watch the video.
VANTAGE recently achieved LEED Gold certification: Read More.
 
VANTAGE Scientific Director:  James Crowe, M.D.
E-Mail: james.crowe@Vanderbilt.Edu

Associate Director, Immunogenetics: Simon Mallal, MBBS
E-Mail: s.mallal@vanderbilt.edu

VANTAGE Associate Director:  Thomas Stricker, M.D., Ph.D.
E-Mail: thomas.stricker@Vanderbilt.Edu

 

Biobanking Services & Low-Throughput Genotyping Manager: Cara Sutcliffe
E-Mail: cara.b.sutcliffe@vanderbilt.edu
Phone: (615) 936-2744

Sequencing, High-Throughput Genotyping & Expression Services Liaison: Lana Olson
E-Mail: lana.m.olson@vanderbilt.edu
Phone: (615) 936-3815

Website: http://vantage.vanderbilt.edu/

Advisory Committee Meetings:
        May 19, 2014

Faculty Advisory Committee Members (2014-2015):

Jim Crowe
Simon Mallal
Yu Shyr
Wei Zheng
Dan Roden
David Miller
Sam Santoro
Roger Cone
Scott Hiebert
David Haas
David Calkins
Al Powers
Eric Skaar

 

 

VANGARD was launched Nov 1, 2012 to help investigators design experiments and analyze and interpret data generated by VANTAGE.  The mission of the core is to consolidate the genomics data pipeline across the university and allow investigators to leverage the opportunities provided by next-generation sequencing and other genomics technologies. VANGARD operates in conjunction with VANTAGE, providing experimental design, quality assessment of data, analysis and results interpretation, and data storage to investigators, while VANTAGE provides technical services with a focus on next-generation sequencing including DNA-seq and RNA-seq. VANGARD also provides biostatistical and bioinformatics support for all genomic experiments that utilize BioVU specimens.  For small-scale projects, VANGARD uses a fee-for-service model which includes basic experimental design and quantitative analysis for genomic data generated by VANTAGE as well as data storage and backup. Large-scale projects and those that require more complex and detailed analysis may be handled collaboratively.

 

For general questions or to request VANGARD services, please contact lana.m.olson@vanderbilt.edu.

VANGARD Leadership Team:

Director:  Yu Shyr, Ph.D.
yu.shyr@vanderbilt.edu

Technical Director for Bioinformatics:  Yan Guo, Ph.D.
yan.guo@vanderbilt.edu

Technical Director for Informatics:  Lynne Berry, Ph.D.
lynne.d.berry@vanderbilt.edu

VANGARD Core Facility Manager:  Lana Olson
lana.m.olson@vanderbilt.edu

VUIIS supports advances in physics, engineering, computing and other clinical and basic sciences for the development and application of new and enhanced imaging techniques to address problems in biology and medicine, in health and disease. Faculty and trainees pursue research in developing new imaging methods and techniques, as well as in diverse applications. The addition of a 7 tesla magnet, one of only about eight in the United States, has enabled researchers to generate images down to the molecular level and will ensure Vanderbilt remains at the forefront of research in magnetic imaging.

Some of the core areas of current interest are the development of methods for the assessment of structure, function, and metabolism including imaging in broad areas such as cancer, brain physiology, transgenic mice, cellular and molecular as well as research into the physics of imaging and spectrometry. The Institute also provides an exemplary training environment for postdoctoral fellow, graduate and medical students and undergraduates.

Center Director: John Gore

Center for Human Imaging
Scientific Director: Seth Smith
Phone: (615) 322-6211
Manager: Brian Welch
Phone: (615) 343-7754
Website: http://www.vuiis.vanderbilt.edu/resources.php

Center for Small Animal Imaging
Center Director: John Gore
Scientific Director: Mark Does
Manager: Jarrod True
Website: http://www.vuiis.vanderbilt.edu/resources.php

Center for Molecular Probes – Radiochemistry
Scientific Director: Charles Manning
Email: henry.c.manning@vanderbilt.edu
Technical Director: Mike Nickels
Email: michael.l.nickels@vanderbilt.edu

Website: http://www.vuiis.vanderbilt.edu/resources.php

The current zebrafish facility is composed of approximately 100 research tanks available for short and long-term studies, and a significant expansion project is underway. The facility enables investigator access to the unique advantages of the zebrafish model, which provides hundreds of mutant and transgenic zebrafish with unique properties suited for specific experiments. This core’s essential mission is to provide a reliable mechanism for incorporation and propagation of new and existing zebrafish lines into the core.
 
Scientific Director: Ela Knapik
E-Mail: ela.knapik@Vanderbilt.Edu
Phone: (615) 322-7569