Lab News

Hutson and Page-McCaw labs publish article in Biophysical Journal.

 

The article, entitled "Multiple Mechanisms Drive Calcium Signal Dynamics around Laser-Induced Epithelial, Wounds", describes how different types of cell and tissue damage result in different mechanisms of signaling to the neighboring healthy cells.  Cells in the center of the wound die immediately, and these transmit an extracellular signal to distant healthy neighbors alerting them to the presence of a wound in the tissue.  Around the dying cells, another ring of cells gets damaged but not killed, and they communicate their wounded status via gap-junction signaling to their healthy next-door neighboring cells.  The surrounding healthy cells interpret both signals as an increase in intracellular calcilum, as shown in this video.  The study comprised the thesis research of Erica Shannon and was published in Biophysical Journal on October 3, 2017.

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Kimi LaFever rises to Lab Manager.

Kimi LaFever, who joined the Page-McCaw lab as an RA2 the day we moved to Vanderbilt in 2010, is being promoted to Lab Manager.  This reclassification is a big move up for her, skipping entirely the intermediate step of RA3.  Kimi's new duties will include more training, organizing, and overseeing.  Kimi first started working with flies in the lab of Daniela Drummond-Barbosa, who then left Vanderbilt for Johns Hopkins in 2009.  Kimi helped Daniela's lab move to Baltimore but wanted to return to her native Tennessee.  She found us, planning a move to Nashville from New York.  We were lucky then -- and we are lucky now to have Kimi continuing with us in this new capacity!

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